2026-04-13T13:32:23Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/128132025-10-24T10:16:43Zcom_2072_378070com_2072_378040col_2072_378092

2025-10-24T10:16:42Z urn:hdl:11351/12813 Mortality, functional outcome and health-related quality of life in patients with necrotizing skin- and soft tissue infections in the ICU: Protocol of a multinational prospective cohort study (SKIN-ICU) Urbina, Tomas Madsen, Martin Hua, Camille Eckmann, Christian Elhadi, Muhammed GURJAR, MOHAN Ferrer, Ricard Pacients - Satisfacció Malalties bacterianes Pell - Necrosi Pell - Infeccions Unitats de cures intensives Amputació DISEASES::Bacterial Infections and Mycoses::Bacterial Infections::Skin Diseases, Bacterial::Fasciitis, Necrotizing ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Surgical Procedures, Operative::Orthopedic Procedures::Amputation HEALTH CARE::Health Care Facilities, Manpower, and Services::Health Facilities::Hospital Units::Intensive Care Units DISEASES::Bacterial Infections and Mycoses::Infection::Soft Tissue Infections HEALTH CARE::Environment and Public Health::Public Health::Epidemiologic Measurements::Demography::Health Status::Quality of Life ENFERMEDADES::infecciones bacterianas y micosis::infecciones bacterianas::enfermedades cutáneas bacterianas::fascitis necrotizante TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::intervenciones quirúrgicas::procedimientos ortopédicos::amputación ATENCIÓN DE SALUD::instalaciones, servicios y personal de asistencia sanitaria::centros sanitarios::unidades hospitalarias::unidades de cuidados intensivos ENFERMEDADES::infecciones bacterianas y micosis::infección::infecciones de los tejidos blandos ATENCIÓN DE SALUD::ambiente y salud pública::salud pública::medidas epidemiológicas::demografía::estado de salud::calidad de vida Adult intensive & critical care; Adult surgery; Necrotizing soft tissue infections Cuidados intensivos y críticos para adultos; Cirugía de adultos; Infecciones necrosantes de tejidos blandos Cures intensives i crítiques per a adults; Cirurgia d'adults; Infeccions necrotitzants de teixits tous Background Necrotizing soft tissue infections (NSTI) are rare and life-threatening bacterial infections characterized by necrosis of subcutaneous tissue, fascia, or muscle. Few prospective studies have been conducted. The primary objective is to assess the 90-day mortality rate and to identify prognostic factors in patients with NSTI in an international setting. Secondary objectives are i) to characterize the clinical and microbiological presentation and management; ii) to assess the risk of limb amputation and associated factors; and iii) to assess functional and health-related quality of life (HRQoL) outcomes and associated factors. Methods We are conducting a multinational, prospective, non-interventional cohort study. We plan to enroll 1,033 consecutive patients admitted to 85 hospitals with surgically proven NSTI between November 2021 and December 2024 in 17 countries over three continents. Data will be collected prospectively on a secure web-based server. The primary outcome measure will be the day-90 mortality. Secondary outcomes include need for limb amputation, the activity of daily living scale and health-related quality of life at day-90 (EQ-5D-5L questionnaire). Baseline characteristics associated with outcomes will be identified by multivariable analyses. Exploratory analyses will be conducted to assess the impact of therapeutic interventions on day-90 mortality and secondary outcomes. The study protocol has been approved by an ethics committee in each participating country. This work was supported by the European Society of Intensive Care Medicine (ESICM) 2020 Next Start-up grant. 2025-10-24T10:16:42Z 2025-10-24T10:16:42Z 2025-03-21T09:43:56Z 2025-03-21T09:43:56Z 2025-03 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/11351/12813 Infectious Diseases Now;55(2) https://doi.org/10.1016/j.idnow.2025.105033 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Elsevier Scientia