2026-04-13T11:52:19Zhttps://recercat.cat/oai/requestoai:recercat.cat:11351/127392025-05-03T03:20:48Zcom_2072_378070com_2072_378040col_2072_378092
RECERCAT
author
Balconi, Francesca
author
Garcia-Alvarez, Alejandro
author
Hernando, Jorge
author
OConnor, Juan Manuel
author
Chacon, Matias
author
Tissera, Natalia Soledad
author
Capdevila Castillon, Jaume
2025-05-03T03:20:48Z
2025-05-03T03:20:48Z
2025-03-11T09:43:46Z2025-03-11T09:43:46Z20242025-01
http://hdl.handle.net/11351/12739
First-line chemotherapy; Maintenance therapy; Neuroendocrine carcinomaQuimioterapia de primera línea; Terapia de mantenimiento; Carcinoma neuroendocrinoQuimioteràpia de primera línia; Teràpia de manteniment; Carcinoma neuroendocríNeuroendocrine carcinomas are rare and aggressive malignancies, often diagnosed at advanced stages, leading to poor prognosis. Platinum-based chemotherapy is the standard first-line treatment for advanced neuroendocrine carcinomas; however after achieving response no consensus exists on maintenance therapies and the results are inconsistent. This review examines the role of maintenance therapy following response to first-line chemotherapy in gastroenteropancreatic neuroendocrine carcinomas. We identified limited supporting evidence, primarily from phase II trials and case reports, that suggested maintenance therapy could be considered for prolonging progression-free survival, balancing toxicity, and maintaining quality of life. Nevertheless, prospective studies are needed to validate its clinical efficacy.
Attribution-NonCommercial 4.0 International http://creativecommons.org/licenses/by-nc/4.0/ info:eu-repo/semantics/openAccess
Aparell digestiu - Càncer - Quimioteràpia
Aparell digestiu - Prevenció
Tumors neuroendocrins
DISEASES::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Germ Cell and Embryonal::Neuroectodermal Tumors::Neuroendocrine Tumors::Carcinoma, Neuroendocrine
Other subheadings::Other subheadings::Other subheadings::/drug therapy
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Drug Therapy::Maintenance Chemotherapy
ENFERMEDADES::neoplasias::neoplasias por tipo histológico::neoplasias de células germinales y embrionarias::tumores neuroectodérmicos::tumores neuroendocrinos::carcinoma neuroendocrino
Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::farmacoterapia::quimioterapia de mantenimiento
Maintenance therapy after first-line platinum-based chemotherapy in gastroenteropancreatic neuroendocrine carcinomas: A literature review
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion