2026-04-14T06:47:00Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/127142025-10-24T10:27:18Zcom_2072_378070com_2072_378040col_2072_378092

Systematic Review and Meta-Analysis of Extracorporeal Photopheresis for the Treatment of Steroid-Refractory Chronic Graft-Versus-Host Disease DeFilipp, Zachariah Holderried, Tobias Mehra, Varun Michonneau, David Pashley, Alex Fox, Maria Laura Institut Català de la Salut [DeFilipp Z] Massachusetts General Hospital, Boston, Massachusetts. [Fox L] Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Holderried TAW] University Hospital Bonn, Bonn, Germany. [Mehra V] King's College Hospital London, London, UK. [Michonneau D] Hôpital Saint-Louis, Assistance Publique des Hôpitaux de Paris, Université Paris Cité, Paris, France. [Pashley A] Costello Medical, Cambridge, UK Vall d'Hebron Barcelona Hospital Campus Avaluació de resultats (Assistència sanitària) Malalties cròniques Esteroides - Ús terapèutic Empelt contra l'hoste, Malaltia de l' - Fototeràpia ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Prognosis::Treatment Outcome DISEASES::Immune System Diseases::Graft vs Host Disease Other subheadings::Other subheadings::/therapy CHEMICALS AND DRUGS::Polycyclic Compounds::Fused-Ring Compounds::Steroids Other subheadings::Other subheadings::/therapeutic use DISEASES::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Chronic Disease ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Phototherapy::Ultraviolet Therapy::PUVA Therapy::Photopheresis TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronóstico::resultado del tratamiento ENFERMEDADES::enfermedades del sistema inmune::enfermedad injerto contra huésped Otros calificadores::Otros calificadores::/terapia COMPUESTOS QUÍMICOS Y DROGAS::compuestos policíclicos::compuestos con anillos de fusión::esteroides Otros calificadores::Otros calificadores::/uso terapéutico ENFERMEDADES::afecciones patológicas, signos y síntomas::procesos patológicos::atributos de la enfermedad::enfermedad crónica TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::fototerapia::tratamiento con rayos ultravioleta::tratamiento PUVA::fotoféresis Chronic graft-versus-host disease; Extracorporeal photopheresis; Steroid-refractory disease Enfermedad crónica de injerto contra huésped; Fotoféresis extracorpórea; Enfermedad refractaria a esteroides Malaltia crònica d'empelt contra hoste; Fotofèresi extracorpòria; Malaltia refractaria als esteroides The objective of this meta-analysis (MA) was to evaluate the efficacy and safety of extracorporeal photopheresis (ECP) for the treatment of steroid-refractory chronic graft-versus-host disease (SR-cGvHD). A systematic literature review (SLR) was conducted according to PRISMA guidelines, followed by a feasibility assessment (FA) to assess potential between-study heterogeneity in the meta-analysis (MA). Random-effects MAs were performed for overall survival (OS), failure-free survival (FFS), overall response rate (ORR) and skin-specific response. A subgroup analysis was conducted to explore the effect of NIH assessment criteria. The SLR identified 627 records; 45 unique studies were ultimately included in the MA. For patients treated with ECP, at Month 12, the pooled OS rate was 83.97% and the pooled FFS rate was 60.79%. ORR was 45.34% at Months 3 to 4 and 58.23% at Months 6 to 8. Subgroup analyses showed no significant difference in ORR between studies utilizing NIH criteria and those utilizing non-NIH criteria. Skin-specific response was 34.86% at Months 2 to 3 and 54.22% at Months 4 to 6. There was considerable heterogeneity across all analyses, with I2 values ranging from 65% to 91%. This SLR and MA indicates that ECP results in favorable outcomes in the treatment of SR-cGvHD, including OS, FFS and ORR. This study was funded by Mallinckrodt Pharmaceuticals. 2025-03-07T11:43:26Z 2025-03-07T11:43:26Z 2024 2025-02 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion DeFilipp Z, Fox L, Holderried TAW, Mehra V, Michonneau D, Pashley A, et al. Systematic Review and Meta-Analysis of Extracorporeal Photopheresis for the Treatment of Steroid-Refractory Chronic Graft-Versus-Host Disease. Transplant Cell Ther. 2025 Feb;31(2):76.e1-76.e13. 2666-6367 http://hdl.handle.net/11351/12714 10.1016/j.jtct.2024.11.004 39536878 001422583500001 http://hdl.handle.net/11351/12714 eng Transplantation and Cellular Therapy;31(2) https://doi.org/10.1016/j.jtct.2024.11.004 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess application/pdf Elsevier Scientia