2026-04-17T20:12:00Zhttps://recercat.cat/oai/requestoai:recercat.cat:11351/127142025-10-24T10:27:18Zcom_2072_378070com_2072_378040col_2072_378092
RECERCAT
author
DeFilipp, Zachariah
author
Holderried, Tobias
author
Mehra, Varun
author
Michonneau, David
author
Pashley, Alex
author
Fox, Maria Laura
2025-10-24T10:27:18Z
2025-10-24T10:27:18Z
2025-03-07T11:43:26Z2025-03-07T11:43:26Z20242025-02
http://hdl.handle.net/11351/12714
Chronic graft-versus-host disease; Extracorporeal photopheresis; Steroid-refractory diseaseEnfermedad crónica de injerto contra huésped; Fotoféresis extracorpórea; Enfermedad refractaria a esteroidesMalaltia crònica d'empelt contra hoste; Fotofèresi extracorpòria; Malaltia refractaria als esteroidesThe objective of this meta-analysis (MA) was to evaluate the efficacy and safety of extracorporeal photopheresis (ECP) for the treatment of steroid-refractory chronic graft-versus-host disease (SR-cGvHD). A systematic literature review (SLR) was conducted according to PRISMA guidelines, followed by a feasibility assessment (FA) to assess potential between-study heterogeneity in the meta-analysis (MA). Random-effects MAs were performed for overall survival (OS), failure-free survival (FFS), overall response rate (ORR) and skin-specific response. A subgroup analysis was conducted to explore the effect of NIH assessment criteria. The SLR identified 627 records; 45 unique studies were ultimately included in the MA. For patients treated with ECP, at Month 12, the pooled OS rate was 83.97% and the pooled FFS rate was 60.79%. ORR was 45.34% at Months 3 to 4 and 58.23% at Months 6 to 8. Subgroup analyses showed no significant difference in ORR between studies utilizing NIH criteria and those utilizing non-NIH criteria. Skin-specific response was 34.86% at Months 2 to 3 and 54.22% at Months 4 to 6. There was considerable heterogeneity across all analyses, with I2 values ranging from 65% to 91%. This SLR and MA indicates that ECP results in favorable outcomes in the treatment of SR-cGvHD, including OS, FFS and ORR.This study was funded by Mallinckrodt Pharmaceuticals.
Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess
Avaluació de resultats (Assistència sanitària)
Malalties cròniques
Esteroides - Ús terapèutic
Empelt contra l'hoste, Malaltia de l' - Fototeràpia
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Prognosis::Treatment Outcome
DISEASES::Immune System Diseases::Graft vs Host Disease
Other subheadings::Other subheadings::/therapy
CHEMICALS AND DRUGS::Polycyclic Compounds::Fused-Ring Compounds::Steroids
Other subheadings::Other subheadings::/therapeutic use
DISEASES::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Chronic Disease
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Phototherapy::Ultraviolet Therapy::PUVA Therapy::Photopheresis
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronóstico::resultado del tratamiento
ENFERMEDADES::enfermedades del sistema inmune::enfermedad injerto contra huésped
Otros calificadores::Otros calificadores::/terapia
COMPUESTOS QUÍMICOS Y DROGAS::compuestos policíclicos::compuestos con anillos de fusión::esteroides
Otros calificadores::Otros calificadores::/uso terapéutico
ENFERMEDADES::afecciones patológicas, signos y síntomas::procesos patológicos::atributos de la enfermedad::enfermedad crónica
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::fototerapia::tratamiento con rayos ultravioleta::tratamiento PUVA::fotoféresis
Systematic Review and Meta-Analysis of Extracorporeal Photopheresis for the Treatment of Steroid-Refractory Chronic Graft-Versus-Host Disease
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion