2026-04-17T02:47:15Zhttps://recercat.cat/oai/requestoai:recercat.cat:11351/127122025-10-24T10:39:19Zcom_2072_378070com_2072_378040col_2072_378092
RECERCAT
author
Calvete, Julio
author
Taylor-Stokes, Gavin
author
Álvarez Ayerza, Néstor
author
Vilanova Larena, David
author
Manley Daumont, Melinda
author
cedres, susana
2025-10-24T10:39:19Z
2025-10-24T10:39:19Z
2025-03-07T11:26:27Z2025-03-07T11:26:27Z20242025-01
http://hdl.handle.net/11351/12712
Health-related quality of life; Malignant pleural mesothelioma; TreatmentCalidad de vida relacionada con la salud; Mesotelioma pleural maligno; TratamientoQualitat de vida relacionada amb la salut; Mesotelioma pleural maligne; TractamentPurpose
Malignant pleural mesothelioma (MPM) is an aggressive cancer with long latency and poor prognosis. The real-world treatment patterns and humanistic burden of MPM in an international cohort of patients were recently published. Spanish data are currently lacking and are reported here.
Methods/Patients
Data were collected from three sources: physician-abstracted demographic, clinical and treatment characteristics of patients with MPM; patient-completed questionnaires on treatment satisfaction, symptoms, caregiver use, and impact of the disease; and caregiver-completed questionnaire reporting their activity and its impact on their daily life.
Results
The 241 patients in Spain were primarily elderly (median age: 67 years), male, retired/unemployed/on long-term sick leave, and diagnosed at stage IV with unresectable disease. Exposure to asbestos was detected (54%, 101/188). First-line treatment (1L) consisted primarily of doublet chemotherapy (86%, 207/241). Of 102 patients who completed 1L at data abstraction, 67 were receiving maintenance therapy, most commonly singlet chemotherapy with pemetrexed. Best supportive care was given to 29 patients, primarily after 1L (86.2%, 25/29). Symptom burden was high and health-related quality of life was poor and declined with progression: mean (SD) EQ-5D score and EQ-5D visual analogue scale score were 0.615 (0.285) and 60.8 (17.1) in 1L and 0.497 (0.370) and 56.1 (19.5) in second line. Overall, 67% of patients (162/241) required daily assistance from their caregiver, who reported an impact on their psychological well-being.
Conclusions
Patients with MPM in Spain were overall treated according to treatment guidelines at the time. Nevertheless, a considerable burden of disease was reported by patients and caregivers.This study was funded by Bristol Myers Squibb.
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess
Qüestionaris
Pleura - Càncer - Tractament
Mesotelioma - Tractament
Pacients - Satisfacció
Assistència sanitària - Cost
DISEASES::Neoplasms::Neoplasms by Site::Thoracic Neoplasms::Respiratory Tract Neoplasms::Pleural Neoplasms
DISEASES::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Glandular and Epithelial::Adenoma::Mesothelioma
Other subheadings::Other subheadings::Other subheadings::/drug therapy
HEALTH CARE::Environment and Public Health::Public Health::Epidemiologic Measurements::Demography::Health Status::Quality of Life
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Epidemiologic Methods::Data Collection::Surveys and Questionnaires
HEALTH CARE::Health Care Economics and Organizations::Economics::Costs and Cost Analysis::Cost of Illness
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias torácicas::neoplasias del tracto respiratorio::neoplasias pleurales
ENFERMEDADES::neoplasias::neoplasias por tipo histológico::neoplasias glandulares y epiteliales::adenoma::mesotelioma
Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia
ATENCIÓN DE SALUD::ambiente y salud pública::salud pública::medidas epidemiológicas::demografía::estado de salud::calidad de vida
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::métodos epidemiológicos::recopilación de datos::encuestas y cuestionarios
ATENCIÓN DE SALUD::economía y organizaciones para la atención de la salud::economía::costes y análisis de costes::coste de las enfermedades
Treatment patterns and humanistic burden of malignant pleural mesothelioma in Spain
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion