2026-04-17T00:45:21Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/126322025-10-24T10:59:29Zcom_2072_451665com_2072_378040col_2072_451666

00925njm 22002777a 4500 dc Roura Blanco, Ignacio author Pardo Ruiz, Jèssica author Martin Barcelo, Cristina author Oltra González, Javier author Campabadal Delgado, Anna author Sala-Llonch, Roser author Pont-Sunyer, Claustre author 2025-02-21T07:48:56Z 2025-02-21T07:48:56Z 2025-01-28 Isolated rapid-eye movement (REM); Magnetic resonance imaging (rsfMRI); Comprehensive neuropsychological testing Movimientos oculares rápidos aislados (REM); Imágenes por resonancia magnética (rsfMRI); Pruebas neuropsicológicas integrales Moviment ocular ràpid aïllat (REM); Imatge de ressonància magnètica (rsfMRI); Proves neuropsicològiques integrals Background: Isolated rapid-eye movement (REM) sleep behavior disorder (iRBD) is characterized by abnormal behaviors in REM sleep and is considered as a prodromal symptom of alpha-synucleinopathies. Resting-state functional magnetic resonance imaging (rsfMRI) studies have unveiled altered functional connectivity (rsFC) in patients with iRBD. However, the associations between intra- and inter-network rsFC with clinical symptoms and neuropsychological functioning in iRBD remain unclear. Objective: To characterize intra- and inter-network rsFC in iRBD patients using a data-driven approach and to assess its associations with clinical features and cognitive functioning. Methods: Forty-two patients with iRBD and 45 healthy controls (HC) underwent rsfMRI and comprehensive neuropsychological testing. Resting-state networks were characterized using independent component analyses. Group differences in intra- and inter-network rsFC and their associations with clinical and neuropsychological data were studied. A threshold of corrected P < 0.05 was used in all the analyses. Results: iRBD patients displayed lower intra-network rsFC within basal ganglia, visual, sensorimotor, and cerebellar networks, relative to HC. Mean rsFC strength within the basal ganglia network positively correlated with processing speed and negatively with the non-motor symptoms in iRBD patients. Reduced inter-network rsFC between sensorimotor and visual medial networks was observed in iRBD patients, which was associated with global cognitive status. Conclusions: iRBD is characterized by both reductions in intra-network rsFC in cortical and subcortical networks and inter-network dysconnectivity between sensorimotor and visual networks. Abnormalities in intra- and inter-network rsFC are associated with cognitive performance and non-motor symptoms, suggesting the utility of both rsFC measures as imaging markers in prodromal alpha-synucleinopathies. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. This study was sponsored by the Spanish Ministry of Economy and Competitiveness (MINECO PID2020-114640GB-I00/ AEI/10.13039/501100011033, PID2023-146932NB-100/AEI/ 110.13039/5011000111033 to C.J. and B.S.), Generalitat de Catalunya (SGR 2021SGR00801) and supported by María de Maeztu Unit of Excellence (Institute of Neurosciences, University of Barcelona) CEX2021-001159-M, Ministry of Science and Innovation. I.R. was supported by a fellowship from La Caixa Foundation (LCF/BQ/ DR22/11950012). J.P. was supported by a fellowship from the Ministry of Science and Innovation (PRE2021–099674). J.O. was supported by a fellowship from the Ministry of Science, Innovation, and Universities (PRE2018-086675). http://hdl.handle.net/11351/12632 Ulls - Moviments Ressonància magnètica Trastorns del son PSYCHIATRY AND PSYCHOLOGY::Behavioral Disciplines and Activities::Behavioral Sciences::Psychophysiology::Neuropsychology DISEASES::Nervous System Diseases::Sleep Wake Disorders::Parasomnias::REM Sleep Parasomnias::REM Sleep Behavior Disorder ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Neuroimaging::Functional Neuroimaging PSIQUIATRÍA Y PSICOLOGÍA::disciplinas y actividades conductuales::ciencias de la conducta::psicofisiología::neuropsicología ENFERMEDADES::enfermedades del sistema nervioso::trastornos del sueño-vigilia::parasomnias::parasomnias del sueño REM::trastorno de la conducta en el sueño REM TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::técnicas y procedimientos diagnósticos::diagnóstico por imagen::neuroimágenes::neuroimágenes funcionales Altered Intra- and Inter-Network Resting-State Functional Connectivity is Associated with Neuropsychological Functioning and Clinical Symptoms in Patients with Isolated Rapid Eye Movement Sleep Behavior Disorder