2026-04-17T20:10:13Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/126272025-10-24T10:25:26Zcom_2072_378070com_2072_378040col_2072_378092

Mitral Transcatheter Edge-to-Edge Repair and Clinical Value of Novel Echocardiographic Biomarkers: A Hypothesis-Generating Study SOLSONA CARAVACA, JAVIER Fernández Galera, Ruben Gonzalez Fernandez, Victor Airale, Lorenzo Rivas, Johny Scudeler, Luca Vallejo Camazón, Nuria Teixido-Tura, Gisela Oliveró, Ruperto Martí Aguasca, Gerard Ferreira González, Ignacio Casas, Guillem Valente, Filipa Belahnech, Yassin García del Blanco, Bruno Rodríguez Palomares, José F Galian-Gay, Laura Ecocardiografia Vàlvula mitral - Cirurgia Cor - Vàlvules - Malalties - Cirurgia Marcadors bioquímics DISEASES::Cardiovascular Diseases::Heart Diseases::Heart Valve Diseases::Mitral Valve Insufficiency Other subheadings::Other subheadings::Other subheadings::/surgery CHEMICALS AND DRUGS::Biological Factors::Biomarkers ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Cardiac Imaging Techniques::Echocardiography ENFERMEDADES::enfermedades cardiovasculares::enfermedades cardíacas::enfermedades de las válvulas cardíacas::insuficiencia mitral Otros calificadores::Otros calificadores::Otros calificadores::/cirugía COMPUESTOS QUÍMICOS Y DROGAS::factores biológicos::biomarcadores TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::técnicas y procedimientos diagnósticos::diagnóstico por imagen::técnicas de imagen cardíaca::ecocardiografía Left atrial strain; Mitral regurgitation; Ventricle–pulmonary artery coupling Tensió auricular esquerra; Insuficiència mitral; Acoblament ventricle-artèria pulmonar Tensión auricular izquierda; Insuficiencia mitral; Acoplamiento ventrículo-arteria pulmonar Background: Longitudinal data on reverse cardiac remodeling and outcomes after transcatheter edge-to-edge repair (TEER) are limited. Methods: A total of 78 patients with severe mitral regurgitation (MR) were included retrospectively. All patients had echocardiography at baseline and again six months after TEER. They were monitored for a primary composite endpoint, consisting of heart failure hospitalization and cardiovascular death, over 13 months. Results: Significant decreases in the left ventricular ejection fraction (LVEF), all myocardial work indices (except global wasted work), and the left atrial reservoir were observed after TEER. Additionally, there was a decrease in the pulmonary artery systolic pressure and an increase in the tricuspid annular plane systolic excursion/pulmonary artery systolic pressure (TAPSE/PASP) ratio. A post-TEER TAPSE/PASP ratio of <0.47 (HR: 4.76, p-value = 0.039), and a post-TEER left atrial reservoir of <9.0% (HR: 2.77, p-value = 0.047) were associated with the primary endpoint. Conclusions: Echocardiography post-TEER reflects impairment in ventricular performance due to preload reduction and right ventricle and pulmonary artery coupling improvement. Short-term echocardiography after TEER identifies high-risk patients who could benefit from a close clinical follow-up. The prognostic significance of LA strain and the TAPSE/PASP ratio should be validated in subsequent large-scale prospective studies. Belahnech, Y. is supported by a research non-conditioned grant (Rio Hortega CM22/00242). 2025-10-24T10:25:26Z 2025-10-24T10:25:26Z 2025-10-24T10:25:26Z 2025-02-19T07:14:24Z 2025-02-19T07:14:24Z 2024-08-01 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/11351/12627 Biomedicines;12(8) https://doi.org/10.3390/biomedicines12081710 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess MDPI Scientia