2026-04-13T13:46:01Zhttps://recercat.cat/oai/requestoai:recercat.cat:11351/126272025-10-24T10:25:26Zcom_2072_378070com_2072_378040col_2072_378092
RECERCAT
author
SOLSONA CARAVACA, JAVIER
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Fernández Galera, Ruben
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Gonzalez Fernandez, Victor
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Airale, Lorenzo
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Rivas, Johny
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Scudeler, Luca
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Vallejo Camazón, Nuria
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Teixido-Tura, Gisela
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Oliveró, Ruperto
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Martí Aguasca, Gerard
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Ferreira González, Ignacio
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Casas, Guillem
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Valente, Filipa
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Belahnech, Yassin
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García del Blanco, Bruno
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Rodríguez Palomares, José F
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Galian-Gay, Laura
2025-10-24T10:25:26Z
2025-10-24T10:25:26Z
2025-02-19T07:14:24Z2025-02-19T07:14:24Z2024-08-01
http://hdl.handle.net/11351/12627
Left atrial strain; Mitral regurgitation; Ventricle–pulmonary artery couplingTensió auricular esquerra; Insuficiència mitral; Acoblament ventricle-artèria pulmonarTensión auricular izquierda; Insuficiencia mitral; Acoplamiento ventrículo-arteria pulmonarBackground: Longitudinal data on reverse cardiac remodeling and outcomes after transcatheter edge-to-edge repair (TEER) are limited.
Methods: A total of 78 patients with severe mitral regurgitation (MR) were included retrospectively. All patients had echocardiography at baseline and again six months after TEER. They were monitored for a primary composite endpoint, consisting of heart failure hospitalization and cardiovascular death, over 13 months.
Results: Significant decreases in the left ventricular ejection fraction (LVEF), all myocardial work indices (except global wasted work), and the left atrial reservoir were observed after TEER. Additionally, there was a decrease in the pulmonary artery systolic pressure and an increase in the tricuspid annular plane systolic excursion/pulmonary artery systolic pressure (TAPSE/PASP) ratio. A post-TEER TAPSE/PASP ratio of <0.47 (HR: 4.76, p-value = 0.039), and a post-TEER left atrial reservoir of <9.0% (HR: 2.77, p-value = 0.047) were associated with the primary endpoint.
Conclusions: Echocardiography post-TEER reflects impairment in ventricular performance due to preload reduction and right ventricle and pulmonary artery coupling improvement. Short-term echocardiography after TEER identifies high-risk patients who could benefit from a close clinical follow-up. The prognostic significance of LA strain and the TAPSE/PASP ratio should be validated in subsequent large-scale prospective studies.Belahnech, Y. is supported by a research non-conditioned grant (Rio Hortega CM22/00242).
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess
Ecocardiografia
Vàlvula mitral - Cirurgia
Cor - Vàlvules - Malalties - Cirurgia
Marcadors bioquímics
DISEASES::Cardiovascular Diseases::Heart Diseases::Heart Valve Diseases::Mitral Valve Insufficiency
Other subheadings::Other subheadings::Other subheadings::/surgery
CHEMICALS AND DRUGS::Biological Factors::Biomarkers
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Cardiac Imaging Techniques::Echocardiography
ENFERMEDADES::enfermedades cardiovasculares::enfermedades cardíacas::enfermedades de las válvulas cardíacas::insuficiencia mitral
Otros calificadores::Otros calificadores::Otros calificadores::/cirugía
COMPUESTOS QUÍMICOS Y DROGAS::factores biológicos::biomarcadores
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::técnicas y procedimientos diagnósticos::diagnóstico por imagen::técnicas de imagen cardíaca::ecocardiografía
Mitral Transcatheter Edge-to-Edge Repair and Clinical Value of Novel Echocardiographic Biomarkers: A Hypothesis-Generating Study
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion