2026-04-17T17:00:05Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/126272025-10-24T10:25:26Zcom_2072_378070com_2072_378040col_2072_378092

00925njm 22002777a 4500 dc SOLSONA CARAVACA, JAVIER author Fernández Galera, Ruben author Gonzalez Fernandez, Victor author Airale, Lorenzo author Rivas, Johny author Scudeler, Luca author Vallejo Camazón, Nuria author Teixido-Tura, Gisela author Oliveró, Ruperto author Martí Aguasca, Gerard author Ferreira González, Ignacio author Casas, Guillem author Valente, Filipa author Belahnech, Yassin author García del Blanco, Bruno author Rodríguez Palomares, José F author Galian-Gay, Laura author 2025-02-19T07:14:24Z 2025-02-19T07:14:24Z 2024-08-01 Left atrial strain; Mitral regurgitation; Ventricle–pulmonary artery coupling Tensió auricular esquerra; Insuficiència mitral; Acoblament ventricle-artèria pulmonar Tensión auricular izquierda; Insuficiencia mitral; Acoplamiento ventrículo-arteria pulmonar Background: Longitudinal data on reverse cardiac remodeling and outcomes after transcatheter edge-to-edge repair (TEER) are limited. Methods: A total of 78 patients with severe mitral regurgitation (MR) were included retrospectively. All patients had echocardiography at baseline and again six months after TEER. They were monitored for a primary composite endpoint, consisting of heart failure hospitalization and cardiovascular death, over 13 months. Results: Significant decreases in the left ventricular ejection fraction (LVEF), all myocardial work indices (except global wasted work), and the left atrial reservoir were observed after TEER. Additionally, there was a decrease in the pulmonary artery systolic pressure and an increase in the tricuspid annular plane systolic excursion/pulmonary artery systolic pressure (TAPSE/PASP) ratio. A post-TEER TAPSE/PASP ratio of <0.47 (HR: 4.76, p-value = 0.039), and a post-TEER left atrial reservoir of <9.0% (HR: 2.77, p-value = 0.047) were associated with the primary endpoint. Conclusions: Echocardiography post-TEER reflects impairment in ventricular performance due to preload reduction and right ventricle and pulmonary artery coupling improvement. Short-term echocardiography after TEER identifies high-risk patients who could benefit from a close clinical follow-up. The prognostic significance of LA strain and the TAPSE/PASP ratio should be validated in subsequent large-scale prospective studies. Belahnech, Y. is supported by a research non-conditioned grant (Rio Hortega CM22/00242). http://hdl.handle.net/11351/12627 Ecocardiografia Vàlvula mitral - Cirurgia Cor - Vàlvules - Malalties - Cirurgia Marcadors bioquímics DISEASES::Cardiovascular Diseases::Heart Diseases::Heart Valve Diseases::Mitral Valve Insufficiency Other subheadings::Other subheadings::Other subheadings::/surgery CHEMICALS AND DRUGS::Biological Factors::Biomarkers ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Cardiac Imaging Techniques::Echocardiography ENFERMEDADES::enfermedades cardiovasculares::enfermedades cardíacas::enfermedades de las válvulas cardíacas::insuficiencia mitral Otros calificadores::Otros calificadores::Otros calificadores::/cirugía COMPUESTOS QUÍMICOS Y DROGAS::factores biológicos::biomarcadores TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::técnicas y procedimientos diagnósticos::diagnóstico por imagen::técnicas de imagen cardíaca::ecocardiografía Mitral Transcatheter Edge-to-Edge Repair and Clinical Value of Novel Echocardiographic Biomarkers: A Hypothesis-Generating Study