2026-04-13T04:44:56Zhttps://recercat.cat/oai/requestoai:recercat.cat:11351/125982025-10-24T07:47:05Zcom_2072_451665com_2072_378040col_2072_451666
RECERCAT
author
Martínez, Esther
author
Foncillas, Alberto
author
Téllez, Adrián
author
Fernández, Sara
author
Martínez‑Nadal, Gemma
author
Rico Caballero, Veronica
2025-10-24T07:47:05Z
2025-10-24T07:47:05Z
2025-02-17T07:43:27Z2025-02-17T07:43:27Z2024-10-11
http://hdl.handle.net/11351/12598
Acquired immunodeficiency syndrome (AIDS); Antiretroviral therapy; Intensive care unitSíndrome de inmunodeficiencia adquirida (SIDA); Terapia antirretroviral; Unidad de cuidados intensivosSíndrome d'immunodeficiència adquirida (SIDA); Teràpia antiretroviral; Unitat de cures intensivesPurposes: Since 2016, the World Health Organization has recommended universal antiretroviral therapy (ART) for all people living with Human Immunodeficiency Virus (PLHIV). This recommendation may have influenced the characteristics and outcomes of PLHIV admitted to the Intensive Care Unit (ICU). This study aims to identify changes in the epidemiological and clinical characteristics of PLHIV admitted to the ICU, and their short- and medium-term outcomes before and after the implementation of universal ART (periods 2006-2015 and 2016-2019).
Methods: This retrospective, observational, single-center study included all adult PLHIV admitted to the ICU of a University Hospital in Barcelona from 2006 to 2019.
Results: The study included 502 admissions involving 428 patients, predominantly men (75%) with a median (P25-P75) age of 47.5 years (39.7-53.9). Ninety-one percent were diagnosed with HIV before admission, with 82% under ART and 60% admitted from the emergency department. In 2016-2019, there were more patients on ART pre-admission, reduced needs for invasive mechanical ventilation (IMV) and fewer in-ICU complications. ICU mortality was also lower (14% vs 7%). Predictors of in-ICU mortality included acquired immunodeficiency syndrome defining event (ADE)-related admissions, ICU complications, higher SOFA scores, IMV and renal replacement therapy (RRT) requirement. ART use during ICU admission was protective. Higher SOFA scores, admission from hospital wards, and more comorbidities predicted one-year mortality.
Conclusions: The in-ICU mortality of critically ill PLHIV has decreased in recent years, likely due to changes in patient characteristics. Pre- and ICU admission features remain the primary predictors of short- and medium-term outcomes
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess
Sida
Unitats de cures intensives
Epidemiologia
DISEASES::Virus Diseases::RNA Virus Infections::Retroviridae Infections::Lentivirus Infections::HIV Infections::Acquired Immunodeficiency Syndrome
HEALTH CARE::Health Care Facilities, Manpower, and Services::Health Facilities::Hospital Units::Intensive Care Units
PUBLIC HEALTH::Epidemiology and Biostatistics::Epidemiology::Epidemiologic Studies::Analytical Epidemiology
ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Retroviridae::infecciones por Lentivirus::infecciones por VIH::síndrome de inmunodeficiencia adquirida
ATENCIÓN DE SALUD::instalaciones, servicios y personal de asistencia sanitaria::centros sanitarios::unidades hospitalarias::unidades de cuidados intensivos
SALUD PÚBLICA::epidemiología y bioestadística::epidemiología::estudios epidemiológicos::epidemiología analítica
Epidemiological changes and outcomes of people living with HIV admitted to the intensive care unit: a 14-year retrospective study
info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion