2026-04-17T15:03:19Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/125982025-10-24T07:47:05Zcom_2072_451665com_2072_378040col_2072_451666

00925njm 22002777a 4500 dc Martínez, Esther author Foncillas, Alberto author Téllez, Adrián author Fernández, Sara author Martínez‑Nadal, Gemma author Rico Caballero, Veronica author 2025-02-17T07:43:27Z 2025-02-17T07:43:27Z 2024-10-11 Acquired immunodeficiency syndrome (AIDS); Antiretroviral therapy; Intensive care unit Síndrome de inmunodeficiencia adquirida (SIDA); Terapia antirretroviral; Unidad de cuidados intensivos Síndrome d'immunodeficiència adquirida (SIDA); Teràpia antiretroviral; Unitat de cures intensives Purposes: Since 2016, the World Health Organization has recommended universal antiretroviral therapy (ART) for all people living with Human Immunodeficiency Virus (PLHIV). This recommendation may have influenced the characteristics and outcomes of PLHIV admitted to the Intensive Care Unit (ICU). This study aims to identify changes in the epidemiological and clinical characteristics of PLHIV admitted to the ICU, and their short- and medium-term outcomes before and after the implementation of universal ART (periods 2006-2015 and 2016-2019). Methods: This retrospective, observational, single-center study included all adult PLHIV admitted to the ICU of a University Hospital in Barcelona from 2006 to 2019. Results: The study included 502 admissions involving 428 patients, predominantly men (75%) with a median (P25-P75) age of 47.5 years (39.7-53.9). Ninety-one percent were diagnosed with HIV before admission, with 82% under ART and 60% admitted from the emergency department. In 2016-2019, there were more patients on ART pre-admission, reduced needs for invasive mechanical ventilation (IMV) and fewer in-ICU complications. ICU mortality was also lower (14% vs 7%). Predictors of in-ICU mortality included acquired immunodeficiency syndrome defining event (ADE)-related admissions, ICU complications, higher SOFA scores, IMV and renal replacement therapy (RRT) requirement. ART use during ICU admission was protective. Higher SOFA scores, admission from hospital wards, and more comorbidities predicted one-year mortality. Conclusions: The in-ICU mortality of critically ill PLHIV has decreased in recent years, likely due to changes in patient characteristics. Pre- and ICU admission features remain the primary predictors of short- and medium-term outcomes http://hdl.handle.net/11351/12598 Sida Unitats de cures intensives Epidemiologia DISEASES::Virus Diseases::RNA Virus Infections::Retroviridae Infections::Lentivirus Infections::HIV Infections::Acquired Immunodeficiency Syndrome HEALTH CARE::Health Care Facilities, Manpower, and Services::Health Facilities::Hospital Units::Intensive Care Units PUBLIC HEALTH::Epidemiology and Biostatistics::Epidemiology::Epidemiologic Studies::Analytical Epidemiology ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Retroviridae::infecciones por Lentivirus::infecciones por VIH::síndrome de inmunodeficiencia adquirida ATENCIÓN DE SALUD::instalaciones, servicios y personal de asistencia sanitaria::centros sanitarios::unidades hospitalarias::unidades de cuidados intensivos SALUD PÚBLICA::epidemiología y bioestadística::epidemiología::estudios epidemiológicos::epidemiología analítica Epidemiological changes and outcomes of people living with HIV admitted to the intensive care unit: a 14-year retrospective study