2026-04-17T23:27:13Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/125852025-10-24T10:15:38Zcom_2072_378070com_2072_378040col_2072_378092

Usefulness of Xpert MTB/RIF and Xpert Ultra to Categorize Risk of Tuberculosis Transmission to Household Contacts mol, Alexander Bosch-Nicolau, Pau Saborit Braceros, Núria Broto Cortés, Claudia SÁNCHEZ-MONTALVÁ, ADRIÁN Espinosa-Pereiro, Juan Aznar, María Luisa Salvador, Fernando de Souza Galvão, Maria Luiza Jiménez-Fuentes, María Ángeles Rodrigo Pendás, José Ángel Molina Romero, Israel Tórtola Fernández, María Teresa Institut Català de la Salut [Mol A, Saborit N, Broto C] Servei de Malalties Infeccioses, Vall d’Hebron Hospital Universitari, Barcelona, Spain. PROSICS Barcelona, Barcelona, Spain. [Sánchez-Montalvá A] Servei de Malalties Infeccioses, Vall d’Hebron Hospital Universitari, Barcelona, Spain. PROSICS Barcelona, Barcelona, Spain. Grupo de Estudio de Infecciones por Micobacterias, Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica, Madrid, Spain. Center for Biomedical Research in Infectious Diseases Network, Instituto de Salud Carlos III, Madrid, Spain. Department of Medicine, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Espinosa-Pereiro J] Servei de Malalties Infeccioses, Vall d’Hebron Hospital Universitari, Barcelona, Spain. PROSICS Barcelona, Barcelona, Spain. Grupo de Estudio de Infecciones por Micobacterias, Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica, Madrid, Spain. Department of Medicine, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Aznar ML, Salvador F, Bosch-Nicolau P, Molina I] Servei de Malalties Infeccioses, Vall d’Hebron Hospital Universitari, Barcelona, Spain. PROSICS Barcelona, Barcelona, Spain. Center for Biomedical Research in Infectious Diseases Network, Instituto de Salud Carlos III, Madrid, Spain. Department of Medicine, Universitat Autònoma de Barcelona, Bellaterra, Spain. [de Souza-Galvão ML, Jiménez MÁ] Servei de Pulmonologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Rodrigo-Pendás JÁ] Servei de Medicina Preventiva i Epidemiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Tórtola T] Servei de Microbiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain Vall d'Hebron Barcelona Hospital Campus Esput Tuberculosi - Diagnòstic Tuberculosi - Transmissió Tests de sensibilitat microbiològica DISEASES::Bacterial Infections and Mycoses::Bacterial Infections::Gram-Positive Bacterial Infections::Actinomycetales Infections::Mycobacterium Infections::Tuberculosis::Tuberculosis, Pulmonary Other subheadings::Other subheadings::/diagnosis ANATOMY::Fluids and Secretions::Bodily Secretions::Sputum ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Microbiological Techniques::Microbial Sensitivity Tests ENFERMEDADES::infecciones bacterianas y micosis::infecciones bacterianas::infecciones por bacterias grampositivas::infecciones por Actinomycetales::micobacteriosis::tuberculosis::tuberculosis pulmonar Otros calificadores::Otros calificadores::/diagnóstico ANATOMÍA::líquidos y secreciones::secreciones corporales::esputo TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::técnicas y procedimientos diagnósticos::técnicas de laboratorio clínico::técnicas microbiológicas::pruebas de sensibilidad microbiana Contact investigation; Risk of transmission; Tuberculosis Investigación de contactos; Riesgo de transmisión; Tuberculosis Recerca de contactes; Risc de transmissió; Tuberculosi Background People with pulmonary tuberculosis (PTB) are contagious, particularly to their household contacts. Their infectivity has been associated with the bacterial load in sputum samples. This study investigated if the bacterial load in sputum samples as quantified by Xpert MTB/RIF and Xpert Ultra is correlated with the extent that latent tuberculosis infection (LTBI) occurred in household contacts of people with PTB. Methods A retrospective study was performed including people with PTB presenting at Vall d’Hebron University Hospital, Barcelona, between 2011 and 2021. Their infection ratio, representing the proportion of household members found with LTBI in contact tracing investigation, was compared with the quantitative results of Xpert MTB/RIF and Xpert Ultra using ordinal regression analysis. Results A total of 107 people with PTB were included. Among their 398 household contacts, 126 (31.7%) cases of LTBI and 14 cases with active TB disease (3.5%) were reported. Higher bacterial load in Xpert MTB/RIF and Xpert Ultra baseline sputum was significantly associated with increased infection ratios, providing better estimates than conventional acid-fast bacilli (AFB) smear grading. Conclusions Xpert MTB/RIF and Xpert Ultra could serve as an alternative to AFB sputum-smear grading in determining contact tracing priorities. 2025-02-11T12:52:58Z 2025-02-11T12:52:58Z 2024-08 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Mol A, Sánchez-Montalvá A, Espinosa-Pereiro J, Aznar ML, Salvador F, Bosch-Nicolau P, et al. Usefulness of Xpert MTB/RIF and Xpert Ultra to Categorize Risk of Tuberculosis Transmission to Household Contacts. Open Forum Infect Dis. 2024 Aug;11(8):ofae450. 2328-8957 https://hdl.handle.net/11351/12585 10.1093/ofid/ofae450 39165580 001293762100001 http://hdl.handle.net/11351/12585 eng Open Forum Infectious Diseases;11(8) https://doi.org/10.1093/ofid/ofae450 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess application/pdf Oxford University Press Scientia