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oai:recercat.cat:11351/125842025-10-24T08:51:50Zcom_2072_378070com_2072_378040com_2072_378071col_2072_378092col_2072_378097

Current perspectives in the management of sepsis and septic shock Ruiz Sanmartin, Adolfo Bajaña Mindiolaza, Ivan Rene Bastidas, Juliana Lopez-Martinez, Rocio Franco-Jarava, Clara Chiscano Camon, Luis González-López, Juan José Riera del Brio, Jordi Ruiz-Rodriguez, Juan Carlos Ferrer, Ricard Larrosa, María Nieves Nuvials, Xavier Institut Català de la Salut [Chiscano-Camón L, Ruiz-Rodríguez JC, Ferrer R] Servei de Medicina Intensiva, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Grup de Recerca de Shock, Disfunció Orgànica i Ressuscitació, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Ruiz-Sanmartin A, Bajaña I, Bastidas J, Riera J, Nuvials-Casals X] Servei de Medicina Intensiva, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Grup de Recerca de Shock, Disfunció Orgànica i Ressuscitació, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Lopez-Martinez R, Franco-Jarava C] Servei d’Immunologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [González JJ, Larrosa N] Servei de Microbiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain Vall d'Hebron Barcelona Hospital Campus Septicèmia - Tractament Xoc sèptic - Tractament Medicina personalitzada Marcadors bioquímics Fenotip DISEASES::Bacterial Infections and Mycoses::Infection::Sepsis::Shock, Septic Other subheadings::Other subheadings::/therapy DISEASES::Bacterial Infections and Mycoses::Infection::Sepsis Other subheadings::Other subheadings::/therapy CHEMICALS AND DRUGS::Biological Factors::Biomarkers PHENOMENA AND PROCESSES::Genetic Phenomena::Phenotype ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Precision Medicine ENFERMEDADES::infecciones bacterianas y micosis::infección::sepsis::choque séptico Otros calificadores::Otros calificadores::/terapia ENFERMEDADES::infecciones bacterianas y micosis::infección::sepsis Otros calificadores::Otros calificadores::/terapia COMPUESTOS QUÍMICOS Y DROGAS::factores biológicos::biomarcadores FENÓMENOS Y PROCESOS::fenómenos genéticos::fenotipo TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::medicina de precisión Precision medicine; Sepsis phenotypes; Septic shock Medicina de precisió; Fenotips de sèpsia; Xoc sèptic Medicina de precisión; Fenotipos de sepsis; Shock séptico Within patients with sepsis, there exists significant heterogeneity, and while all patients should receive conventional therapy, there are subgroups of patients who may benefit from specific therapies, often referred to as rescue therapies. Therefore, the identification of these specific patient subgroups is crucial and lays the groundwork for the application of precision medicine based on the development of targeted interventions. Over the years, efforts have been made to categorize sepsis into different subtypes based on clinical characteristics, biomarkers, or underlying mechanisms. For example, sepsis can be stratified into different phenotypes based on the predominant dysregulated host response. These phenotypes can range from hyperinflammatory states to immunosuppressive states and even mixed phenotypes. Each phenotype may require different therapeutic approaches to improve patient outcomes. Rescue strategies for septic shock may encompass various interventions, such as immunomodulatory therapies, extracorporeal support (e.g., ECMO), or therapies targeted at specific molecular or cellular pathways involved in the pathophysiology of sepsis. In recent years, there has been growing interest in precision medicine approaches to sepsis and phenotype identification. Precision medicine aims to tailor treatments to each individual patient based on their unique characteristics and disease mechanisms. 2025-02-11T12:42:31Z 2025-02-11T12:42:31Z 2024-08-15 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Chiscano-Camón L, Ruiz-Sanmartin A, Bajaña I, Bastidas J, Lopez-Martinez R, Franco-Jarava C, et al. Current perspectives in the management of sepsis and septic shock. Front Med. 2024 Aug 15;11:1431791. 2296-858X https://hdl.handle.net/11351/12584 10.3389/fmed.2024.1431791 39211340 001302670300001 http://hdl.handle.net/11351/12584 eng Frontiers in Medicine;11 https://doi.org/10.3389/fmed.2024.1431791 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess application/pdf Frontiers Media Scientia