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oai:recercat.cat:11351/125692025-10-24T10:17:29Zcom_2072_378070com_2072_378040col_2072_378092

The effectiveness of mapping-targeted biopsies on the index lesion in transperineal prostate biopsies Tcholakian, Larisa Alomar, Xavier Barranco, Miguel Paesano, Nahuel Catalá, Violeta Enrique, Trilla Herrera Morote Robles, Juan Institut Català de la Salut [Paesano N, Catalá V, Tcholakian L, Alomar X, Barranco M] Creu Blanca Clinic Barcelona, Catalunya, Spain. [Trilla E, Morote J] Servei d’Urologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Department of Surgery, Universitat Autònoma de Barcelona, Bellaterra, Spain Vall d'Hebron Barcelona Hospital Campus Pròstata - Càncer - Imatgeria Pròstata - Biòpsia DISEASES::Neoplasms::Neoplasms by Site::Urogenital Neoplasms::Genital Neoplasms, Male::Prostatic Neoplasms Other subheadings::Other subheadings::Other subheadings::/diagnostic imaging ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Cytological Techniques::Cytodiagnosis::Biopsy::Image-Guided Biopsy ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias urogenitales::neoplasias de los genitales masculinos::neoplasias de la próstata Otros calificadores::Otros calificadores::Otros calificadores::/diagnóstico por imagen TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::técnicas y procedimientos diagnósticos::técnicas de laboratorio clínico::técnicas citológicas::citodiagnóstico::biopsia::biopsia guiada por imágenes Prostate; Prostatic Neoplasm; Retrospective Studies Próstata; Neoplasia de la próstata; Estudios retrospectivos Pròstata; Neoplàsia de la pròstata; Estudis retrospectius Purpose: To evaluate the effectiveness of mapping-targeted biopsies (MTB) on the index lesion for the detection of clinically significant prostate cancer (csPCa) in transperineal fusion-image prostate biopsies. Materials and methods: A retrospective analysis was conducted on 309 men with suspected PCa who underwent prostate biopsies at the Creu Blanca reference center in Barcelona, Spain. The Prostate Imaging-Reporting and Data System (PI-RADS v.2.1) of the magnetic resonance images (MRI) were reclassified by an expert radiologist reading of pre-biopsy biparametric MRI used for segmentation of suspected lesions. Transperineal MTB of suspicious lesions and 12-core systematic biopsies were performed using the Artemis™ platform. CsPCa was defined as International Society of Urological Pathology grade group ≥ 2. Results: CsPCa was detected in 192 men (62.1%), with detection rates of 6.3% for PI-RADS 2, 26.8% for PI-RADS 3, 87.3% for PI-RADS 4, and 93.1% for PI-RADS 5. MTB of the index lesion identified 185 csPCa (96.3%). CsPCa was detected solely in systematic biopsies in three cases (1.6%), while an additional four cases (2.1%) were identified only in the second suspected lesion. A predictive model for csPCa detection in MTB of the index lesion was developed, with an AUC of 0.918 (95% CI 0.887-0.950). Conclusions: This model had the potential to avoid 23.3% of prostate biopsies without missing additional csPCa cases. MTB of the index lesion was highly effective for identifying csPCa in fusion transperineal prostate biopsies. A developed predictive model successfully reduced the need for almost one quarter of biopsies without missing csPCa cases. 2025-02-10T06:53:08Z 2025-02-10T06:53:08Z 2024-05 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Paesano N, Catalá V, Tcholakian L, Alomar X, Barranco M, Trilla E, et al. The effectiveness of mapping-targeted biopsies on the index lesion in transperineal prostate biopsies. Int Braz J Urol. 2024 May;50(3):296–308. 1677-6119 https://hdl.handle.net/11351/12569 10.1590/S1677-5538.IBJU.2023.0558 38446907 001202820000015 http://hdl.handle.net/11351/12569 eng International Braz J Urol;50(3) https://doi.org/10.1590/S1677-5538.IBJU.2023.0558 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess application/pdf Sociedade Brasileira de Urologia Scientia