2026-04-14T00:01:38Zhttps://recercat.cat/oai/requestoai:recercat.cat:11351/125692025-10-24T10:17:29Zcom_2072_378070com_2072_378040col_2072_378092
RECERCAT
author
Tcholakian, Larisa
author
Alomar, Xavier
author
Barranco, Miguel
author
Paesano, Nahuel
author
Catalá, Violeta
author
Enrique, Trilla Herrera
author
Morote Robles, Juan
2025-10-24T10:17:29Z
2025-10-24T10:17:29Z
2025-02-10T06:53:08Z2025-02-10T06:53:08Z2024-05
http://hdl.handle.net/11351/12569
Prostate; Prostatic Neoplasm; Retrospective StudiesPróstata; Neoplasia de la próstata; Estudios retrospectivosPròstata; Neoplàsia de la pròstata; Estudis retrospectiusPurpose: To evaluate the effectiveness of mapping-targeted biopsies (MTB) on the index lesion for the detection of clinically significant prostate cancer (csPCa) in transperineal fusion-image prostate biopsies.
Materials and methods: A retrospective analysis was conducted on 309 men with suspected PCa who underwent prostate biopsies at the Creu Blanca reference center in Barcelona, Spain. The Prostate Imaging-Reporting and Data System (PI-RADS v.2.1) of the magnetic resonance images (MRI) were reclassified by an expert radiologist reading of pre-biopsy biparametric MRI used for segmentation of suspected lesions. Transperineal MTB of suspicious lesions and 12-core systematic biopsies were performed using the Artemis™ platform. CsPCa was defined as International Society of Urological Pathology grade group ≥ 2.
Results: CsPCa was detected in 192 men (62.1%), with detection rates of 6.3% for PI-RADS 2, 26.8% for PI-RADS 3, 87.3% for PI-RADS 4, and 93.1% for PI-RADS 5. MTB of the index lesion identified 185 csPCa (96.3%). CsPCa was detected solely in systematic biopsies in three cases (1.6%), while an additional four cases (2.1%) were identified only in the second suspected lesion. A predictive model for csPCa detection in MTB of the index lesion was developed, with an AUC of 0.918 (95% CI 0.887-0.950).
Conclusions: This model had the potential to avoid 23.3% of prostate biopsies without missing additional csPCa cases. MTB of the index lesion was highly effective for identifying csPCa in fusion transperineal prostate biopsies. A developed predictive model successfully reduced the need for almost one quarter of biopsies without missing csPCa cases.
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess
Pròstata - Càncer - Imatgeria
Pròstata - Biòpsia
DISEASES::Neoplasms::Neoplasms by Site::Urogenital Neoplasms::Genital Neoplasms, Male::Prostatic Neoplasms
Other subheadings::Other subheadings::Other subheadings::/diagnostic imaging
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Cytological Techniques::Cytodiagnosis::Biopsy::Image-Guided Biopsy
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias urogenitales::neoplasias de los genitales masculinos::neoplasias de la próstata
Otros calificadores::Otros calificadores::Otros calificadores::/diagnóstico por imagen
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::técnicas y procedimientos diagnósticos::técnicas de laboratorio clínico::técnicas citológicas::citodiagnóstico::biopsia::biopsia guiada por imágenes
The effectiveness of mapping-targeted biopsies on the index lesion in transperineal prostate biopsies
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion