2026-04-18T03:36:33Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/125112025-10-24T10:42:05Zcom_2072_378070com_2072_378040col_2072_378092

Cutaneous infections by dematiaceous opportunistic fungi: Diagnosis and management in 11 solid organ transplant recipients Repiso, Trinidad Juárez-Dobjanschi, Cecilia Ferrer Fábrega, Berta Aparicio Español, Gloria Román Broto, Antonio Ferrandiz-Pulido, Carla Ingrid, Lopez-Lerma González-Cruz, Carlos Moreso, Francesc Garcia-Patos Briones, Vicente Martin Gomez, M. Teresa Institut Català de la Salut [Ferrándiz-Pulido C, Repiso T, Juárez-Dobjanschi C, López-Lerma I, Aparicio G, González-Cruz C, García-Patos V] Servei de Dermatologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Martin-Gomez MT] Servei de Microbiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Ferrer B] Servei d’Anatomia Patològica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Moreso F] Servei de Nefrologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Roman A] Servei de Pneumologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain Vall d'Hebron Barcelona Hospital Campus Pell - Infeccions - Cirurgia Pell - Infeccions - Tractament Dermatomicosi Medicaments antifúngics - Ús terapèutic Trasplantació d'òrgans, teixits, etc. NAMED GROUPS::Persons::Transplant Recipients CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Antifungal Agents Other subheadings::Other subheadings::/therapeutic use DISEASES::Bacterial Infections and Mycoses::Mycoses::Phaeohyphomycosis Other subheadings::Other subheadings::/therapy DENOMINACIONES DE GRUPOS::personas::receptores de trasplantes COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::usos terapéuticos::antiinfecciosos::antifúngicos Otros calificadores::Otros calificadores::/uso terapéutico ENFERMEDADES::infecciones bacterianas y micosis::micosis::feohifomicosis Otros calificadores::Otros calificadores::/terapia Cutaneous infection; Dematiaceous fungui; Immunosuppression Infecció cutània; Fongs dematiacis; Immunosupressió Infección cutánea; Hongos dematiáceos; Inmunosupresión Background: The incidence of cutaneous infections by dematiaceous fungi is rising in our environment due to the high number of solid organ transplant recipients (SOTR). Objective: To review our experience in the management of cutaneous phaeohyphomycoses in a Spanish reference centre for dermatological care of SOTR. Methods: Retrospective clinical, histopathological and microbiological review of all SOTR diagnosed of a phaeohyphomycosis in a 7-year period. Results: Eleven SOTR were identified (8 lung and 3 kidney). The lesions were solitary in six patients and multiple in five, affecting mostly the lower extremities. Early lesions showed epidermal hyperplasia and a diffuse dermal suppurative granulomatous infiltrate that was progressively substituted by fibrosis when the lesions were treated. Septated fungal structures with refractile walls were identified. DNA sequencing confirmed the presence of Alternaria spp (8 cases), Cladosporium cladosporioides, Microsphaeropsis arundinis and Exophiala oligosperma. Three patients with single lesions were treated with surgery, while the other 8 required long-term antifungal therapy, including itraconazole, voriconazole and/or terbinafine, combined with surgery and reduction in tacrolimus doses. Conclusion: A clinical, histopathological and microbiological correlation is essential to corroborate this diagnosis. Solitary lesions are easily treated with surgery, but larger or multiple lesions may require long medical treatments combined with surgery and modification of immunosuppressive medication. The list of dematiaceous fungi implicated in cutaneous infections is expanding, in line with the availability of more sophisticated identification methods and the increasing number of immunosuppressed patients. 2025-01-31T11:56:04Z 2025-01-31T11:56:04Z 2019-02 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Ferrándiz-Pulido C, Martin-Gomez MT, Repiso T, Juárez-Dobjanschi C, Ferrer B, López-Lerma I, et al. Cutaneous infections by dematiaceous opportunistic fungi: Diagnosis and management in 11 solid organ transplant recipients. Mycoses. 2019 Feb;62(2):121–7. 1439-0507 https://hdl.handle.net/11351/12511 10.1111/myc.12853 30230044 000457396900005 http://hdl.handle.net/11351/12511 eng Mycoses;62(2) https://doi.org/10.1111/myc.12853 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/restrictedAccess application/pdf Wiley Scientia