2026-04-17T06:48:36Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/124622025-10-24T10:37:40Zcom_2072_378070com_2072_378040col_2072_378092

00925njm 22002777a 4500 dc Bielsa Carrafa, Anna author Ribases, Marta author Hervas, Amaia author Bosch, Rosa author Gastaminza, Xavier author Casas Brugué, Miquel author Ramos-Quiroga, Josep Antoni author 2025-01-22T13:05:54Z 2025-01-22T13:05:54Z 2009-01 Serotoninergic system; Adults; Attention-deficit-hyperactivity disorder Sistema serotoninérgico; Adultos; Trastorno por déficit de atención e hiperactividad Sistema serotoninèrgic; Adults; Trastorn per dèficit d'atenció i hiperactivitat Attention-deficit/hyperactivity disorder (ADHD) is a common psychiatric disorder in which different genetic and environmental susceptibility factors are involved. Several lines of evidence support the view that at least 30% of ADHD patients diagnosed in childhood continue to suffer the disorder during adulthood and that genetic risk factors may play an essential role in the persistence of the disorder throughout lifespan. Genetic, biochemical and pharmacological studies support the idea that the serotonin system participates in the etiology of ADHD. Based on these data, we aimed to analyze single nucleotide polymorphisms across 19 genes involved in the serotoninergic neurotransmission in a clinical sample of 451 ADHD patients (188 adults and 263 children) and 400 controls using a population-based association study. Several significant associations were found after correcting for multiple testing: (1) the DDC gene was strongly associated with both adulthood (P=0.00053; odds ratio (OR)=2.17) and childhood ADHD (P=0.0017; OR=1.90); (2) the MAOB gene was found specifically associated in the adult ADHD sample (P=0.0029; OR=1.90) and (3) the 5HT2A gene showed evidence of association only with the combined ADHD subtype both in adults (P=0.0036; OR=1.63) and children (P=0.0084; OR=1.49). Our data support the contribution of the serotoninergic system in the genetic predisposition to ADHD, identifying common childhood and adulthood ADHD susceptibility factors, associations that are specific to ADHD subtypes and one variant potentially involved in the continuity of the disorder throughout lifespan. Financial support was received from ‘Instituto de Salud Carlos III-FIS’ (PI041267, PI042010, PI040524). SNP genotyping services were provided by the Spanish ‘Centro Nacional de Genotipado’ (CEGEN; www.cegen.org). http://hdl.handle.net/11351/12462 Trastorn per dèficit d'atenció amb hiperactivitat - Aspectes genètics Serotonina - Receptors PSYCHIATRY AND PSYCHOLOGY::Mental Disorders::Neurodevelopmental Disorders::Attention Deficit and Disruptive Behavior Disorders::Attention Deficit Disorder with Hyperactivity CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, Biogenic Amine::Receptors, Serotonin Other subheadings::Other subheadings::Other subheadings::/genetics PHENOMENA AND PROCESSES::Genetic Phenomena::Genotype::Genetic Predisposition to Disease PSIQUIATRÍA Y PSICOLOGÍA::trastornos mentales::trastornos del desarrollo neurológico::trastornos conductuales disruptivos y déficit de atención::trastornos de déficit de atención con hiperactividad COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas de membranas::receptores de superficie celular::receptores de aminas biógenas::receptores de serotonina Otros calificadores::Otros calificadores::Otros calificadores::/genética FENÓMENOS Y PROCESOS::fenómenos genéticos::genotipo::predisposición genética a la enfermedad Exploration of 19 serotoninergic candidate genes in adults and children with attention-deficit/hyperactivity disorder identifies association for 5HT2A, DDC and MAOB