2026-04-13T00:09:56Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/121232025-10-24T10:38:26Zcom_2072_378070com_2072_378040col_2072_378092

00925njm 22002777a 4500 dc Alcalá-González, Luis Gerardo author Nieto Ruiz, Adoración author Accarino, Anna author Azpiroz, Fernando author Malagelada, Carolina author 2024-10-25T08:26:29Z 2024-10-25T08:26:29Z 2024-11 Intestinal dysmotility; Pseudo‐obstruction; Small bowel manometry Dismotilitat intestinal; Pseudo-obstrucció; Manometria de l'intestí prim Dismotilidad intestinal; Pseudo-obstrucción; Manometría del intestino delgado Background The diagnosis of small bowel motility disorders is performed by manometric evaluation of the contractile patterns of the small intestine. Conventional intestinal manometry systems include few pressure sensors at relatively long intervals. We have recently shown that high-resolution jejunal manometry, with multiple closely spaced recording sites, allows the analysis of propagation patterns of intestinal motility in healthy subjects that cannot be detected with conventional manometry. The objective of this pilot study was to explore the feasibility and diagnostic value of high-resolution intestinal manometry in patients with suspected small bowel dysmotility. Methods Prospective pilot study evaluating intestinal motility patterns in 16 consecutive patients (16–61 years; 11 women) with severe, chronic digestive symptoms referred for the evaluation of intestinal motility and in 18 healthy controls (21–38 years; 8 women). A 36-channel high-resolution manometry catheter was orally placed under radiological guidance in the jejunum. Intestinal motility was continuously recorded for 3 h fasting and 2 h after a 450 kcal meal. The manometric recordings were analyzed in two formats: (a) with the high-resolution data from 34 channels and (b) showing only the recordings from 5 channels separated by 7 cm intervals, mimicking a conventional manometry recording. Key Results In the analysis mimicking conventional manometry, abnormal motility criteria were detected in six patients and in no healthy subject [bursts (n = 3), postprandial minute rhythm (n = 1) and myopathic pattern (n = 2)]. These classical dysmotility criteria were also detected by high-resolution manometry. High-resolution analysis detected one or more abnormal findings in seven additional patients that were not observed in any healthy subject, specifically: (a) abnormal propagation of Phase III (n = 3); (b) reduced propagated activity during Fasting Phase II (n = 4); (c) increased propagated activity during Fasting Phase II and postprandial phase (n = 1). Conclusions and Inferences This pilot study suggests that high-resolution intestinal manometry may improve the sensitivity of conventional manometry in the detection of intestinal motor dysfunction. This work was supported by the Instituto de Salud Carlos III and co-financed by the European Union (FEDER/FSE) [PI17/01794]; Ministerio de Ciencia e Innovación (Agencia Estatal de Investigación, PID2021-122295OB-I00); Ciberehd is funded by the Instituto de Salud Carlos III. LA was supported by a scholarship from the Instituto de Salud Carlos III (CM20/00182). http://hdl.handle.net/11351/12123 Intestins - Malalties - Diagnòstic Tracte gastrointestinal - Motilitat Intestins - Obstrucció DISEASES::Digestive System Diseases::Gastrointestinal Diseases::Intestinal Diseases ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Manometry PHENOMENA AND PROCESSES::Digestive System and Oral Physiological Phenomena::Digestive System Physiological Phenomena::Gastrointestinal Motility DISEASES::Digestive System Diseases::Gastrointestinal Diseases::Intestinal Diseases::Intestinal Obstruction::Ileus::Intestinal Pseudo-Obstruction ENFERMEDADES::enfermedades del sistema digestivo::enfermedades gastrointestinales::enfermedades intestinales TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::manometría FENÓMENOS Y PROCESOS::fenómenos fisiológicos orales y del sistema digestivo::fenómenos fisiológicos del sistema digestivo::motilidad gastrointestinal ENFERMEDADES::enfermedades del sistema digestivo::enfermedades gastrointestinales::enfermedades intestinales::obstrucción intestinal::ileus::seudoobstrucción intestinal High-resolution versus conventional manometry for the diagnosis of small bowel motor dysfunction