2026-04-05T10:42:37Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/120832025-10-24T10:40:54Zcom_2072_378070com_2072_378040col_2072_378092

Unraveling wasp sensitization in a patient with systemic mastocytosis by CAP-inhibition assay Valero, Helena Luengo Sánchez, Olga Cardona, Victoria Pereira González, Javier Labrador-Horrillo, Moises Al·lèrgia a les picades d'insectes Abelles - Verí Mastocitosi Anafilaxi - Immunoteràpia DISEASES::Immune System Diseases::Hypersensitivity::Immune Complex Diseases::Mastocytosis::Mastocytosis, Systemic CHEMICALS AND DRUGS::Complex Mixtures::Venoms::Arthropod Venoms::Wasp Venoms Other subheadings::Other subheadings::Other subheadings::/immunology DISEASES::Chemically-Induced Disorders::Poisoning::Bites and Stings::Insect Bites and Stings DISEASES::Immune System Diseases::Hypersensitivity::Hypersensitivity, Immediate::Anaphylaxis ENFERMEDADES::enfermedades del sistema inmune::hipersensibilidad::enfermedades por complejos inmunes::mastocitosis::mastocitosis sistémica COMPUESTOS QUÍMICOS Y DROGAS::mezclas complejas::ponzoñas::venenos de artrópodos::venenos de avispas Otros calificadores::Otros calificadores::Otros calificadores::/inmunología ENFERMEDADES::trastornos inducidos químicamente::intoxicación::mordeduras y picaduras::mordeduras y picaduras de insectos ENFERMEDADES::enfermedades del sistema inmune::hipersensibilidad::hipersensibilidad inmediata::anafilaxia Hymenoptera venom allergy; Indolent systemic mastocytosis; Venom immunotherapy Alergia al veneno de himenópteros; Mastocitosis sistémica indolente; Inmunoterapia con veneno Al·lèrgia al verí dels himenòpters; Mastocitosi sistèmica indolent; Immunoteràpia con verí Systemic mastocytosis (SM) is a clonal mast cell disorder that can lead to potentially severe anaphylactic reactions. Hymenoptera sting is one of the most frequent triggers of anaphylaxis in these patients, and diagnosis of indolent SM (ISM) without skin involvement (ISMs) is not rare. In this subgroup of patients, venom immunotherapy (VIT) is an effective treatment decreasing subsequent systemic reactions, and lifelong administration is recommended. An individualized diagnosis is necessary to offer the most adequate VIT, and molecular diagnosis (MD) may be useful to discriminate between primary sensitization and cross-reactivity. Nevertheless, other techniques such as ImmunoCAP inhibition assays may be necessary to identify the genuine sensitization to offer the most suitable VIT. We present a male patient with an anaphylactic reaction following several wasp stings. The patient was diagnosed with ISM, and allergy to both Polistes dominula and Vespula sp venom was confirmed. In this scenario, MD did not discriminate between a genuine double sensitization and venom cross-reactivity between both vespids. Thus, CAP-inhibition assay was performed. This case indicated the importance of an accurate diagnosis of hymenoptera venom allergy (HVA). It also highlights the usefulness of CAP-inhibition assays when MD fails to distinguish between genuine double Polistes-Vespula sensitization and cross-reactivity. 2025-10-24T10:40:54Z 2025-10-24T10:40:54Z 2024-10-21T06:55:04Z 2024-10-21T06:55:04Z 2024-09-02 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/11351/12083 Allergologia et Immunopathologia;52(5) https://doi.org/10.15586/aei.v52i5.1142 Attribution-NonCommercial-ShareAlike 4.0 International http://creativecommons.org/licenses/by-nc-sa/4.0/ info:eu-repo/semantics/openAccess Codon Publications Scientia