2026-04-17T06:07:45Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/120712025-10-24T10:40:54Zcom_2072_378070com_2072_378040col_2072_378092

00925njm 22002777a 4500 dc Sanmartín Sánchez, Alicia author Cabrera César, Eva Belén author Espíldora-Hernández, Francisco author Amaya-Campos, María del Mar author Vegas-Aguilar, Isabel María author Palmas, Fiorella author Fernandez Jimenez, Rocio author 2024-10-16T11:47:08Z 2024-10-16T11:47:08Z 2024-08-28 Body composition; Computed tomography; Idiopathic pulmonary fibrosis Composición corporal; Tomografía computarizada; Fibrosis pulmonar idiopática Composició corporal; Tomografia computeritzada; Fibrosi pulmonar idiopàtica Background: Body composition (BC) techniques, including bioelectrical impedance analysis (BIVA), nutritional ultrasound® (NU), and computed tomography (CT), can detect nutritional diagnoses such as sarcopenia (Sc). Sc in idiopathic pulmonary fibrosis (IPF) is associated with greater severity and lower survival. Our aim was to explore the correlation of BIVA, NU and functional parameters with BC at T12 level CT scans in patients with IPF but also its relationship with degree of Sc, malnutrition and mortality. Methods: This bicentric cross-sectional study included 60 IPF patients (85.2% male, 70.9 ± 7.8 years). Morphofunctional assessment (MFA) techniques included BIVA, NU, CT at T12 level (T12-CT), handgrip strength, and timed up and go. CT data were obtained using FocusedON®. Statistical analysis was conducted using JAMOVI version 2.3.22 to determine the cutoff points for Sc in T12-CT and to analyze correlations with other MFA techniques. Results: the cutoff for muscle area in T12-CT was ≤77.44 cm2 (area under the curve (AUC) = 0.734, sensitivity = 41.7%, specificity = 100%). The skeletal muscle index (SMI_T12CT) cutoff was ≤24.5 cm2/m2 (AUC = 0.689, sensitivity = 66.7%, specificity = 66.7%). Low SMI_T12CT exhibited significantly reduced median survival and higher risk of mortality compared to those with normal muscle mass (SMI cut off ≥ 28.8 cm/m2). SMI_T12CT was highly correlated with body cell mass from BIVA (r = 0.681) and rectus femoris cross-sectional area (RF-CSA) from NU (r = 0.599). Cronbach’s α for muscle parameters across different MFA techniques and CT was 0.735, confirming their validity for evaluating muscle composition. Conclusions: T12-CT scan is a reliable technique for measuring low muscle mass in patients with IPF, specifically when the L3 vertebrae are not captured. An SMI value of <28.8 is a good predictor of low lean mass and 12-month mortality in IPF patients. This research was funded by FRESENEIUS KABI. The APC was funded by FRESENIUS KABI. http://hdl.handle.net/11351/12071 Cos - Composició Atròfia muscular - Diagnòstic Atròfia muscular - Tomografia Fibrosi pulmonar DISEASES::Respiratory Tract Diseases::Lung Diseases::Lung Diseases, Interstitial::Idiopathic Interstitial Pneumonias::Idiopathic Pulmonary Fibrosis ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Image Interpretation, Computer-Assisted::Tomography, X-Ray Computed PHENOMENA AND PROCESSES::Physiological Phenomena::Body Constitution::Body Composition DISEASES::Nervous System Diseases::Neurologic Manifestations::Neuromuscular Manifestations::Muscular Atrophy::Sarcopenia Other subheadings::Other subheadings::/diagnosis ENFERMEDADES::enfermedades respiratorias::enfermedades pulmonares::enfermedades pulmonares intersticiales::neumonías intersticiales idiopáticas::fibrosis pulmonar idiopática TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::técnicas y procedimientos diagnósticos::diagnóstico por imagen::interpretación de imágenes asistida por ordenador::tomografía computarizada por rayos X FENÓMENOS Y PROCESOS::fenómenos fisiológicos::constitución corporal::composición corporal ENFERMEDADES::enfermedades del sistema nervioso::manifestaciones neurológicas::manifestaciones neuromusculares::atrofia muscular::sarcopenia Otros calificadores::Otros calificadores::/diagnóstico IA-Body Composition CT at T12 in Idiopathic Pulmonary Fibrosis: Diagnosing Sarcopenia and Correlating with Other Morphofunctional Assessment Techniques