2026-04-14T06:50:47Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/119702025-10-24T10:30:40Zcom_2072_378070com_2072_378040col_2072_378092

00925njm 22002777a 4500 dc Green, Darrell author Tirtei, Elisa author Andreou, Dimosthenis author Baecklund, Fredrik author Baumhoer, Daniel author van Ewijk, Roelof author Valverde, Claudia María author 2024-09-26T12:15:50Z 2024-09-26T12:15:50Z 2024-08-15 Biological sample; Treatment; Osteosarcoma Muestras biológicas; Tratamiento; Osteosarcoma Mostres biològiques; Tractament; Osteosarcoma Osteosarcoma and Ewing sarcoma are bone tumors mostly diagnosed in children, adolescents, and young adults. Despite multimodal therapy, morbidity is high and survival rates remain low, especially in the metastatic disease setting. Trials investigating targeted therapies and immunotherapies have not been groundbreaking. Better understanding of biological subgroups, the role of the tumor immune microenvironment, factors that promote metastasis, and clinical biomarkers of prognosis and drug response are required to make progress. A prerequisite to achieve desired success is a thorough, systematic, and clinically linked biological analysis of patient samples, but disease rarity and tissue processing challenges such as logistics and infrastructure have contributed to a lack of relevant samples for clinical care and research. There is a need for a Europe-wide framework to be implemented for the adequate and minimal sampling, processing, storage, and analysis of patient samples. Two international panels of scientists, clinicians, and patient and parent advocates have formed the Fight Osteosarcoma Through European Research consortium and the Euro Ewing Consortium. The consortia shared their expertise and institutional practices to formulate new guidelines. We report new reference standards for adequate and minimally required sampling (time points, diagnostic samples, and liquid biopsy tubes), handling, and biobanking to enable advanced biological studies in bone sarcoma. We describe standards for analysis and annotation to drive collaboration and data harmonization with practical, legal, and ethical considerations. This position paper provides comprehensive guidelines that should become the new standards of care that will accelerate scientific progress, promote collaboration, and improve outcomes. The Bone Cancer Research Trust (https://www.bcrt.org.uk/) funds FOSTER and EEC structure and activities. E.A. Roundhill and L. Cottone received funding from the Bone Cancer Research Trust (grant numbers BCRT/8422 and /7721). S. Hecker-Nolting received funding from Foerderkreis Krebskranke Kinder e.V. Stuttgart and the German Child Cancer Foundation (grant number DKS 2021.13). The consortia also thank Esperanza Perez, the Institut Gustave Roussy, Société Française des Cancers et leucémies de l’Enfant et de l’adolescent, ATTRACT, Enfants Cancers Santé, INTERSARC, une Main Vers l’Espoir, Imagine for Margo, The George Pantziarka TP53 Trust, German Cancer Aid (DKH), German Child Cancer Foundation (DKS), Society for Pediatric Oncology and Hematology (GPOH), Scandinavian Sarcoma Group, Trust Paola Gonzato Rete Sarcoma Onlus, Myrovlytis Trust, Ludovica’s Parente, InfoCilento, and The Christie Charity for more specific support. http://hdl.handle.net/11351/11970 Espècimens biològics Sarcoma d'Ewing - Càncer - Tractament Osteosarcoma - Càncer - Tractament HEALTH CARE::Health Care Facilities, Manpower, and Services::Health Facilities::Biological Specimen Banks DISEASES::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Connective and Soft Tissue::Neoplasms, Connective Tissue::Neoplasms, Bone Tissue::Osteosarcoma DISEASES::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Connective and Soft Tissue::Neoplasms, Connective Tissue::Neoplasms, Bone Tissue::Osteosarcoma::Sarcoma, Ewing HEALTH CARE::Health Services Administration::Patient Care Management::Disease Management ATENCIÓN DE SALUD::instalaciones, servicios y personal de asistencia sanitaria::centros sanitarios::bancos de muestras biológicas ENFERMEDADES::neoplasias::neoplasias por tipo histológico::neoplasias de tejido conjuntivo y de tejidos blandos::neoplasias de tejido conjuntivo::neoplasias de tejido óseo::osteosarcoma ENFERMEDADES::neoplasias::neoplasias por tipo histológico::neoplasias de tejido conjuntivo y de tejidos blandos::neoplasias de tejido conjuntivo::neoplasias de tejido óseo::osteosarcoma::sarcoma de Ewing ATENCIÓN DE SALUD::administración de los servicios de salud::gestión de la atención al paciente::tratamiento de las enfermedades Biological Sample Collection to Advance Research and Treatment: A Fight Osteosarcoma Through European Research and Euro Ewing Consortium Statement