2026-04-18T07:11:42Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/119552024-11-01T01:13:38Zcom_2072_378070com_2072_378040col_2072_378092

Determinants of Metastatic Colorectal Cancer With Permanent Liver- Limited Disease Garcia Rodriguez, Ariadna Salvà, Francesc Saoudi Gonzalez, Nadia R Castells, Marta Baraibar, Iosune Ros, Javier Tabernero, Josep Elez, Elena Institut Català de la Salut Servei d’Oncologia Mèdica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain Vall d'Hebron Barcelona Hospital Campus Metàstasi Recte - Càncer - Aspectes genètics Còlon - Càncer - Aspectes genètics Fetge - Càncer DISEASES::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms Other subheadings::Other subheadings::Other subheadings::/genetics DISEASES::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Liver Neoplasms DISEASES::Neoplasms::Neoplastic Processes::Neoplasm Metastasis ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias del sistema digestivo::neoplasias gastrointestinales::neoplasias intestinales::neoplasias colorrectales Otros calificadores::Otros calificadores::Otros calificadores::/genética ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias del sistema digestivo::neoplasias hepáticas ENFERMEDADES::neoplasias::procesos neoplásicos::metástasis neoplásica Colorectal cancer; Liver limited disease; Liver metastasis Càncer colorectal; Malaltia limitada del fetge; Metàstasi hepàtica Cáncer colorrectal; Enfermedad limitada al hígado; Metástasis hepática Colorectal cancer (CRC) is a complex and genetically heterogeneous disease presenting a specific metastatic pattern, with the liver being the most common site of metastasis. Around 20%-25% of patients with CRC will develop exclusively hepatic metastatic disease throughout their disease history. With its specific characteristics and therapeutic options, liver-limited disease (LLD) should be considered as a specific entity. The identification of these patients is particularly relevant in view of the growing interest in liver transplantation in selected patients with advanced CRC. Identifying why some patients will develop only LLD remains a challenge, mainly because of a lack of a systemic understanding of this complex and interlinked phenomenon given that cancer has traditionally been investigated according to distinct physiological compartments. Recently, multidisciplinary efforts and new diagnostic tools have made it possible to study some of these complex issues in greater depth and may help identify targets and specific treatment strategies to benefit these patients. In this review we analyze the underlying biology and available tools to help clinicians better understand this increasingly common and specific disease. 2024-09-20T12:11:50Z 2024-09-20T12:11:50Z 2024-09 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Salvà F, Saoudi N, Rodríguez M, Baraibar I, Ros J, García A, et al. Determinants of Metastatic Colorectal Cancer With Permanent Liver- Limited Disease. Clin Colorectal Cancer. 2024 Sep;23(3):207–14. 1533-0028 https://hdl.handle.net/11351/11955 10.1016/j.clcc.2024.05.010 38981843 http://hdl.handle.net/11351/11955 eng Clinical Colorectal Cancer;23(3) https://doi.org/10.1016/j.clcc.2024.05.010 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess application/pdf Elsevier Scientia