2026-04-19T11:38:00Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/117512025-10-24T10:42:10Zcom_2072_378070com_2072_378040col_2072_378092

Echocardiography-Derived Hemodynamic Forces Are Associated with Clinical Outcomes in Patients with Non-Ischemic Dilated Cardiomyopathy Cesareo, Marco Riccardo Ródenas-Alesina, Eduard Casas, Guillem Vallelonga, Fabrizio Ferreira González, Ignacio Guala, Andrea Lozano Torres, Jordi Rodríguez Palomares, José F Institut Català de la Salut [Cesareo M] Hypertension Unit, Division of Internal Medicine, University Hospital Città della Salute e della Scienza of Turin, Turin, Italy. Department of Medical Sciences, University of Turin, Turin, Italy. [Ródenas-Alesina E, Rodriguez-Palomares JF] Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. Centro de Investigación Biomédica en Red-Enfermedades Cardiovaculares (CIBERCV), Madrid, Spain. [Guala A] Centro de Investigación Biomédica en Red-Enfermedades Cardiovaculares (CIBERCV), Madrid, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Lozano-Torres J] Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Casas G] Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Centro de Investigación Biomédica en Red-Enfermedades Cardiovaculares (CIBERCV), Madrid, Spain. [Vallelonga F] Department of Medical Sciences, University of Turin, Turin, Italy. Division of Internal Medicine, Candiolo Cancer Institute-Fondazione del Piemonte per l’Oncologia (FPO)-Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Turin, Italy. [Ferreira-González I] Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain Vall d'Hebron Barcelona Hospital Campus Cor - Ventricle esquerre - Malalties - Factors de risc Ecocardiografia Miocardi - Malalties - Imatgeria Cor - Hipertròfia Hemodinàmica PHENOMENA AND PROCESSES::Circulatory and Respiratory Physiological Phenomena::Cardiovascular Physiological Phenomena::Hemodynamics DISEASES::Cardiovascular Diseases::Heart Diseases::Cardiomegaly::Cardiomyopathy, Dilated Other subheadings::Other subheadings::Other subheadings::/diagnostic imaging ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Cardiac Imaging Techniques::Echocardiography DISEASES::Cardiovascular Diseases::Heart Diseases::Ventricular Dysfunction::Ventricular Dysfunction, Left FENÓMENOS Y PROCESOS::fenómenos fisiológicos respiratorios y circulatorios::fenómenos fisiológicos cardiovasculares::hemodinámica ENFERMEDADES::enfermedades cardiovasculares::enfermedades cardíacas::cardiomegalia::miocardiopatía dilatada Otros calificadores::Otros calificadores::Otros calificadores::/diagnóstico por imagen TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::técnicas y procedimientos diagnósticos::diagnóstico por imagen::técnicas de imagen cardíaca::ecocardiografía ENFERMEDADES::enfermedades cardiovasculares::enfermedades cardíacas::disfunción ventricular::disfunción ventricular izquierda Dilated cardiomyopathy; Echocardiography; Hemodynamic forces Miocardiopatía dilatada; Ecocardiografía; Fuerzas hemodinámicas Miocardiopatia dilatada; Ecocardiografia; Forces hemodinàmiques Introduction: Non-ischemic dilated cardiomyopathy (NIDCM) is characterized by a reduced left ventricular (LV) ejection fraction (LVEF, <50%) and a high risk for heart failure (HF) and death. Echocardiography-derived hemodynamic forces (HDFs) may provide important information on LV mechanics, but their prognostic value is unknown. Aim: To explore the features of echocardiography-derived HDFs in NIDCM and their association with clinical endpoints. Methods: Asymptomatic, non-hospitalized NIDCM patients free from coronary artery disease and moderate or severe valvular heart disease were included in this single-center observational retrospective longitudinal study. Those with atrial fibrillation and a follow-up <12 months were excluded. Major adverse cardiovascular events (MACE) were defined as a composite of all-cause death, HF hospitalization, and ambulatory intravenous diuretics administration. LV HDFs were analyzed with a prototype software. Apex-base (HDFs-ab), lateral-septal (HDFs-ls), and HDFs-angle were computed. Results: Ninety-seven patients were included, sixty-seven (69%) were males, mean age was 62 ± 14 years, and mean LVEF was 39.2 ± 8.6%. During a median follow-up of 4.2 (3.1–5.1) years, 19 (20%) patients experienced MACE. These patients had a higher HDFs-angle (71.0 (67.0–75.0) vs. 68.0 (63.0–71.0)°, p = 0.005), lower HDFs-ls (1.36 (1.01–1.85) vs. 1.66 ([1.28–2.04])%, p = 0.015), but similar HDFs-ab (5.02 (4.39–6.34) vs. 5.66 (4.53–6.78)%, p = 0.375) compared to those without MACE. in a Cox regression analysis, HDFs-angle (HR 1.16 (95%-CI 1.04–1.30), p = 0.007) was associated with MACE, while other conventional echocardiography parameters, including LVEF and LV longitudinal strain, were not. Conclusions: HDFs-angle is associated with clinical endpoints in NIDCM. A higher HDFs-angle may be a marker of impaired myocardial performance in patients with reduced LVEF. A.G. has received funding from “La Caixa” Foundation (LCF/BQ/PR22/11920008). 2024-07-22T06:30:20Z 2024-07-22T06:30:20Z 2024-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Cesareo M, Ródenas-Alesina E, Guala A, Lozano-Torres J, Casas G, Vallelonga F, et al. Echocardiography-Derived Hemodynamic Forces Are Associated with Clinical Outcomes in Patients with Non-Ischemic Dilated Cardiomyopathy. J Clin Med. 2024 Jun 30;13(13):3862. 2077-0383 https://hdl.handle.net/11351/11751 10.3390/jcm13133862 38999432 http://hdl.handle.net/11351/11751 eng Journal of Clinical Medicine;13(13) https://doi.org/10.3390/jcm13133862 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess application/pdf MDPI Scientia