2026-04-13T01:39:28Zhttps://recercat.cat/oai/requestoai:recercat.cat:11351/117472025-10-24T10:17:48Zcom_2072_378070com_2072_378040col_2072_378092
RECERCAT
author
Oertel, Frederike Cosima
author
Zimmermann, Hanna
author
Motamedi, Seyedamirhosein
author
Bereuter, charlotte
author
Manthey, Luca
author
Ashtari, Fereshteh
author
Cobo-Calvo, Alvaro
2025-10-24T10:17:48Z
2025-10-24T10:17:48Z
2024-07-19T11:58:02Z2024-07-19T11:58:02Z2024-09
http://hdl.handle.net/11351/11747
Retina; Neuromyelitis optica spectrum disorders; AntibodyRetina; Trastornos del espectro de la neuromielitis óptica; AnticuerpoRetina; Trastorns de l'espectre de la neuromielitis òptica; AnticòsBackground and Objectives
To systematically describe the clinical picture of double-antibody seronegative neuromyelitis optica spectrum disorders (DN-NMOSD) with specific emphasis on retinal involvement.
Methods
Cross-sectional data of 25 people with DN-NMOSD (48 eyes) with and without a history of optic neuritis (ON) were included in this study along with data from 25 people with aquaporin-4 antibody seropositive neuromyelitis optica spectrum disorder (AQP4-NMOSD, 46 eyes) and from 25 healthy controls (HCs, 49 eyes) for comparison. All groups were matched for age and sex and included from the collaborative retrospective study of retinal optical coherence tomography (OCT) in neuromyelitis optica (CROCTINO). Participants underwent OCT with central postprocessing and local neurologic examination and antibody testing. Retinal neurodegeneration was quantified as peripapillary retinal nerve fiber layer thickness (pRNFL) and combined ganglion cell and inner plexiform layer thickness (GCIPL).
Results
This DN-NMOSD cohort had a history of [median (inter–quartile range)] 6 (5; 9) attacks within their 5 ± 4 years since onset. Myelitis and ON were the most common attack types. In DN-NMOSD eyes after ON, pRNFL (p < 0.001) and GCIPL (p = 0.023) were thinner compared with eyes of HCs. Even after only one ON episode, DN-NMOSD eyes already had considerable neuroaxonal loss compared with HCs. In DN-NMOSD eyes without a history of ON, pRNFL (p = 0.027) and GCIPL (p = 0.022) were also reduced compared with eyes of HCs. However, there was no difference in pRNFL and GCIPL between DN-NMOSD and AQP4-NMOSD for the whole group and for subsets with a history of ON and without a history of ON—as well as between variances of retinal layer thicknesses.
Discussion
DN-NMOSD is characterized by severe retinal damage after ON and attack-independent retinal neurodegeneration. Most of the damage occurs during the first ON episode, which highlights the need for better diagnostic markers in DN-NMOSD to facilitate an earlier diagnosis as well as for effective and early treatments. In this study, people with DN-NMOSD presented with homogeneous clinical and imaging findings potentially suggesting a common retinal pathology in these patients.The authors acknowledge support from the Guthy Jackson Charitable Foundation (GJCF) (to Friedemann Paul).
Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess
Autoanticossos
Nervi òptic - Malalties - Imatgeria
Ulls - Tomografia
Coherència (Òptica)
DISEASES::Nervous System Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Myelitis, Transverse::Neuromyelitis Optica
Other subheadings::Other subheadings::Other subheadings::/diagnostic imaging
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Optical Imaging::Tomography, Optical::Tomography, Optical Coherence
CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Autoantibodies
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades autoinmunitarias del sistema nervioso::enfermedades autoinmunes desmielinizantes del SNC::mielitis transversa::neuromielitis óptica
Otros calificadores::Otros calificadores::Otros calificadores::/diagnóstico por imagen
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::técnicas y procedimientos diagnósticos::diagnóstico por imagen::imágenes ópticas::tomografía óptica::tomografía de coherencia óptica
COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas sanguíneas::inmunoproteínas::inmunoglobulinas::anticuerpos::autoanticuerpos
Retinal Changes in Double-Antibody Seronegative Neuromyelitis Optica Spectrum Disorders
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion