2026-04-17T05:31:06Zhttps://recercat.cat/oai/requestoai:recercat.cat:11351/117462025-10-24T10:22:33Zcom_2072_378070com_2072_378040col_2072_378092
RECERCAT
author
Salva de Torres, Clara
author
Alcaraz Soler, Adriana
author
Garcia Rodriguez, Ariadna
author
Baraibar, Iosune
author
Saoudi Gonzalez, Nadia
author
Ros, Javier
author
Salvà, Francesc
author
R Castells, Marta
author
Tabernero, Josep
author
Elez, Elena
2025-10-24T10:22:33Z
2025-10-24T10:22:33Z
2024-07-19T11:56:45Z2024-07-19T11:56:45Z2024-06-26
http://hdl.handle.net/11351/11746
Cancer biology; Colorectal cancer; Immune checkpoint inhibitorsBiologia del càncer; Càncer colorectal; Inhibidors de punts de control immunitariBiología del cáncer; Cáncer colorrectal; Inhibidores de puntos de control inmunitarioThe treatment of unresectable metastatic colorectal cancer has evolved over the last two decades, as knowledge of cancer biology has broadened and new targets have emerged. ‘The Hallmarks of Cancer’ illustrate the crucial capabilities acquired by cells to become malignant and represent the evolution of knowledge of tumor biology. This review integrates these novel targets and therapies into selected hallmarks: sustaining proliferative signaling, inducing vasculature, avoiding immune destruction, genome instability and mutation, reprogramming cellular metabolism, and resisting cell death. The different strategies and combinations under study are based on treatments with anti-EGFR, anti-VEGF, and anti-HER2 agents, KRAS G12C inhibitors, BRAF and MEK inhibitors, and immune checkpoint inhibitors. However, new approaches are emerging, including vaccines, WEE1 inhibitors, and PARP inhibitors, among others. The further deciphering of cancer biology will unravel new targets, develop novel therapies, and improve patients’ outcomes.
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess
Recte - Càncer - Tractament
Còlon - Càncer - Tractament
Farmacologia molecular
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Drug Therapy::Molecular Targeted Therapy
DISEASES::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms
Other subheadings::Other subheadings::Other subheadings::/drug therapy
CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Antineoplastic Agents
Other subheadings::Other subheadings::/therapeutic use
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::farmacoterapia::terapia molecular selectiva
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias del sistema digestivo::neoplasias gastrointestinales::neoplasias intestinales::neoplasias colorrectales
Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia
COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::usos terapéuticos::antineoplásicos
Otros calificadores::Otros calificadores::/uso terapéutico
Current and Emerging Treatment Paradigms in Colorectal Cancer: Integrating Hallmarks of Cancer
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion