2026-04-19T19:16:13Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/117462025-10-24T10:22:33Zcom_2072_378070com_2072_378040col_2072_378092

00925njm 22002777a 4500 dc Salva de Torres, Clara author Alcaraz Soler, Adriana author Garcia Rodriguez, Ariadna author Baraibar, Iosune author Saoudi Gonzalez, Nadia author Ros, Javier author Salvà, Francesc author R Castells, Marta author Tabernero, Josep author Elez, Elena author 2024-07-19T11:56:45Z 2024-07-19T11:56:45Z 2024-06-26 Cancer biology; Colorectal cancer; Immune checkpoint inhibitors Biologia del càncer; Càncer colorectal; Inhibidors de punts de control immunitari Biología del cáncer; Cáncer colorrectal; Inhibidores de puntos de control inmunitario The treatment of unresectable metastatic colorectal cancer has evolved over the last two decades, as knowledge of cancer biology has broadened and new targets have emerged. ‘The Hallmarks of Cancer’ illustrate the crucial capabilities acquired by cells to become malignant and represent the evolution of knowledge of tumor biology. This review integrates these novel targets and therapies into selected hallmarks: sustaining proliferative signaling, inducing vasculature, avoiding immune destruction, genome instability and mutation, reprogramming cellular metabolism, and resisting cell death. The different strategies and combinations under study are based on treatments with anti-EGFR, anti-VEGF, and anti-HER2 agents, KRAS G12C inhibitors, BRAF and MEK inhibitors, and immune checkpoint inhibitors. However, new approaches are emerging, including vaccines, WEE1 inhibitors, and PARP inhibitors, among others. The further deciphering of cancer biology will unravel new targets, develop novel therapies, and improve patients’ outcomes. http://hdl.handle.net/11351/11746 Recte - Càncer - Tractament Còlon - Càncer - Tractament Farmacologia molecular ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Drug Therapy::Molecular Targeted Therapy DISEASES::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms Other subheadings::Other subheadings::Other subheadings::/drug therapy CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Antineoplastic Agents Other subheadings::Other subheadings::/therapeutic use TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::farmacoterapia::terapia molecular selectiva ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias del sistema digestivo::neoplasias gastrointestinales::neoplasias intestinales::neoplasias colorrectales Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::usos terapéuticos::antineoplásicos Otros calificadores::Otros calificadores::/uso terapéutico Current and Emerging Treatment Paradigms in Colorectal Cancer: Integrating Hallmarks of Cancer