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Safety and efficacy of parsaclisib in combination with rituximab, bendamustine + rituximab, or ibrutinib in patients with previously treated B-cell lymphoma: analysis of a phase 1 dose-finding study (CITADEL‑112) SANCHO, JUAN-MANUEL Kumar, Abhijeet Cordoba, Raul Tani, Monica Langmuir, Peter Abrisqueta, Pau Institut Català de la Salut [Sancho JM] Clinical Hematology Department, IJC, Hospital Germans Trias i Pujol, Institut Català d’Oncologia, Barcelona, Spain. [Abrisqueta P] Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Servei de Hematologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Kumar A] University of Arizona, Tucson, AZ, USA. [Cordoba R] Lymphoma Unit, Department of Hematology, Fundacion Jimenez Diaz University Hospital, Health Research Institute IIS-FJD, Madrid, Spain. [Tani M] Haematology Unit Santa Maria delle Croci Hospital, Ravenna, Italy. [Langmuir P] Incyte Corporation, Wilmington, DE, USA Vall d'Hebron Barcelona Hospital Campus Avaluació de resultats (Assistència sanitària) Quimioteràpia combinada Medicaments antineoplàstics - Ús terapèutic Cèl·lules B - Tumors - Tractament ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Prognosis::Treatment Outcome ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Therapeutics::Drug Therapy::Antineoplastic Protocols::Therapeutics::Drug Therapy::Antineoplastic Combined Chemotherapy Protocols DISEASES::Neoplasms::Neoplasms by Histologic Type::Lymphoma::Lymphoma, Non-Hodgkin::Lymphoma, B-Cell TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronóstico::resultado del tratamiento TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapéutica::farmacoterapia::protocolos antineoplásicos::terapéutica::farmacoterapia::protocolos de quimioterapia antineoplásica combinada ENFERMEDADES::neoplasias::neoplasias por tipo histológico::linfoma::linfoma no Hodgkin::linfoma de células B Bendamustine; Ibrutinib; Non-Hodgkin lymphoma Bendamustina; Ibrutinib; Linfoma no Hodgkin Bendamustina; Ibrutinib; Limfoma no Hodgkin Parsaclisib, a potent and highly selective phosphoinositide 3-kinase δ inhibitor, has shown clinical activity in relapsed/refractory (R/R) B-cell lymphoma. The phase 1 CITADEL-112 (NCT03424122) study assessed safety and efficacy of parsaclisib in combination with investigator choice standard of care (SOC; rituximab [Treatment A], rituximab plus bendamustine [Treatment B], or ibrutinib [Treatment C]) in 50 patients with R/R B-cell lymphoma. The most common treatment-emergent adverse events included neutropenia (62.5%, 50.0%, and 50.0% of patients in Treatments A, B, and C, respectively); diarrhea (37.5%) and anemia (31.3%) in Treatment A; abdominal pain, asthenia, diarrhea, and nausea (each 33.3%) in Treatment B; and increased alanine and aspartate aminotransferase (each 37.5%) in Treatment C. Objective responses were observed in 13 patients (81.3%) in Treatment A, 10 (55.6%) in Treatment B, and 8 (50.0%) in Treatment C. Parsaclisib combined with SOC therapies had an expected safety profile and promising efficacy in patients with R/R B-cell lymphomas. This study was supported by Incyte Corporation (Wilmington, DE, USA). 2024-07-09T09:43:24Z 2024-07-09T09:43:24Z 2024-07 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Sancho JM, Abrisqueta P, Kumar A, Cordoba R, Tani M, Langmuir P, et al. Safety and efficacy of parsaclisib in combination with rituximab, bendamustine + rituximab, or ibrutinib in patients with previously treated B-cell lymphoma: analysis of a phase 1 dose-finding study (CITADEL‑112). Leuk Lymphoma. 2024 Jul;65(7):911–921. 1029-2403 https://hdl.handle.net/11351/11681 10.1080/10428194.2024.2331626 38598516 001199980400001 eng Leukemia & Lymphoma;65(7) https://doi.org/10.1080/10428194.2024.2331626 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess application/pdf Taylor & Francis Scientia