2026-04-05T10:51:26Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/116762025-10-24T10:41:56Zcom_2072_378070com_2072_378040col_2072_378092

Natural history and surgical outcomes of Rathke’s cleft cysts: a Spanish multicenter study Menéndez Torre, Edelmiro Gutiérrez-Hurtado, Alba Ollero, María Dolores Irigaray, Ana Martín, Patricia Parra Ramírez, Paola Biagetti, Betina Avaluació de resultats (Assistència sanitària) Quistos Sistema nerviós central - Càncer - Cirurgia Hipòfisi ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Prognosis::Treatment Outcome DISEASES::Neoplasms::Neoplasms by Site::Nervous System Neoplasms::Central Nervous System Neoplasms::Central Nervous System Cysts Other subheadings::Other subheadings::Other subheadings::/surgery DISEASES::Neoplasms::Neoplasms by Site::Endocrine Gland Neoplasms::Pituitary Neoplasms TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronóstico::resultado del tratamiento ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias del sistema nervioso::neoplasias del sistema nervioso central::quistes del sistema nervioso central Otros calificadores::Otros calificadores::Otros calificadores::/cirugía ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de las glándulas endocrinas::neoplasias hipofisarias Rathke’s cleft cyst; Transsphenoidal surgery; Visual impairment Quiste de hendidura de Rathke; Hipófisis; Cirugía transesfenoidal Quist de fendedura de Rathke; Hipòfisi; Cirurgia transesfenoïdal Rathke’s cleft cysts (RCC) are a common type of lesion found in the sellar or suprasellar area. They are usually monitored clinically, but in some cases, surgery may be required. However, their natural progression is not yet well understood, and the outcomes of surgery are uncertain. The objective of this study is to evaluate the natural history of Rathke’s cleft cysts in patients who are clinically monitored without treatment, and to determine the outcomes of surgery and the incidence of recurrences over time. Design and patients: National multicentric study of patients diagnosed of Rathke’s cleft cyst (RCC- Spain) from 2000 onwards and followed in 15 tertiary centers of Spain. A total of 177 patients diagnosed of RCC followed for 67.3 months (6–215) and 88 patients who underwent surgery, (81 patients underwent immediate surgery after diagnosis and 7 later for subsequent growth) followed for 68.8 months (3–235). Results: The cyst size remained stable or decreased in 73.5% (133) of the patients. Only 44 patients (24.3%) experienced a cyst increase and 9 of them (5.1%) experienced an increase greater than 3 mm. In most of the patients who underwent surgery headaches and visual alterations improved, recurrence was observed in 8 (9.1%) after a median time of 96 months, and no predictors of recurrence were discovered. Conclusions: Rathke’s cleft cysts without initial compressive symptoms have a low probability of growth, so conservative management is recommended. Patients who undergo transsphenoidal surgery experience rapid clinical improvement, and recurrences are infrequent. However, they can occur after a long period of time, although no predictors of recurrence have been identified. 2025-10-24T10:41:56Z 2025-10-24T10:41:56Z 2024-07-08T06:24:44Z 2024-07-08T06:24:44Z 2024-06-17 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/11351/11676 Frontiers in Endocrinology;15 https://doi.org/10.3389/fendo.2024.1413810 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Frontiers Media Scientia