2026-04-03T19:04:49Zhttps://recercat.cat/oai/requestoai:recercat.cat:11351/116642025-10-24T10:21:59Zcom_2072_451665com_2072_378040com_2072_378070col_2072_451666col_2072_378092
RECERCAT
author
Tur-Martínez, Jaume
author
Rodriguez Santiago, Joaquin
author
Osorio, Javier
author
Miró, Mònica
author
Yárnoz, María Concepción
author
Jofra Castells, Mariona
author
Aldeano, Aurora
2025-10-24T10:21:59Z
2025-10-24T10:21:59Z
2024-07-04T09:45:35Z2024-07-04T09:45:35Z2024-06-11
http://hdl.handle.net/11351/11664
Gastric cancer; Preoperative biomarker; Preoperative immune scoreCáncer gástrico; Biomarcador preoperatorio; Puntuación inmunológico preoperatorioCàncer gàstric; Biomarcador preoperatori; Puntuació immunològica preoperatòriaBackground: The aim of this study was to evaluate different preoperative immune, inflammatory, and nutritional scores and their best cut-off values as predictors of poorer overall survival (OS) and disease-free survival (DFS) in patients who underwent curative gastric cancer resection. Methods: This was a retrospective observational multicentre study based on data of the Spanish EURECCA Esophagogastric Cancer Registry. Time-dependent Youden index and log-rank test were used to obtain the best cut-offs of 18 preoperative biomarkers for OS and DFS. An adjusted Cox model with variables selected by bootstrapping was used to identify the best preoperative biomarkers, which were also analysed for every TNM stage. Results: High neutrophil-to-lymphocyte ratio (NLR), high monocyte systemic inflammation index (moSII), and low prognostic nutritional index (PNI) were identified as independent predictors of poor outcome: NLR > 5.91 (HR:1.73; 95%CI [1.23–2.43]), moSII >2027.12 (HR:2.26; 95%CI [1.36–3.78]), and PNI >40.31 (HR:0.75; 95%CI [0.58–0.96]) for 5-year OS and NLR > 6.81 (HR:1.75; 95%CI [1.24–2.45]), moSII > 2027.12 (HR:2.46; 95%CI [1.49–4.04]), and PNI > 40.31 (HR:0.77; 95%CI [0.60,0.97]) for 5-year DFS. These outcomes were maintained in the whole cohort for NLR and moSII (p < 0.05) but not in stage II and for PNI in all tumoral stages. The associations of NLR-PNI and moSII-PNI were also a relevant prognostic factor for OS. Conclusions: High NLR, high moSII (for stages I and III), and low PNI (regardless of tumour stage) were the most promising preoperative biomarkers to predict poor OS and DFS in gastric cancer patients treated with curative intent.
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess
Estómac - Càncer - Cirurgia
Estómac - Càncer - Prognosi
Marcadors bioquímics
Gastrectomia
CHEMICALS AND DRUGS::Biological Factors::Biomarkers
DISEASES::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Stomach Neoplasms
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Surgical Procedures, Operative::Digestive System Surgical Procedures::Gastrectomy
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Prognosis
COMPUESTOS QUÍMICOS Y DROGAS::factores biológicos::biomarcadores
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias del sistema digestivo::neoplasias gastrointestinales::neoplasias gástricas
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::intervenciones quirúrgicas::procedimientos quirúrgicos del sistema digestivo::gastrectomía
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronóstico
Prognostic Relevance of Preoperative Immune, Inflammatory, and Nutritional Biomarkers in Patients Undergoing Gastrectomy for Resectable Gastric Adenocarcinoma: An Observational Multicentre Study
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion