2026-04-17T04:30:41Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/115712025-10-24T10:32:56Zcom_2072_378070com_2072_378040col_2072_378092

00925njm 22002777a 4500 dc Llàcer Iborra, Pau author Gayan Ordas, Jara author Zegri-Reiriz, Isabel author Fort, Aleix author Cobo Marcos, Marta author De la Espriella, Rafael author Méndez Fernández, Ana Belén author Soler, María José author 2024-06-10T10:40:23Z 2024-06-10T10:40:23Z 2024-05-15 Albuminuria; Cardiorenal disease; Congestion Albuminúria; Malaltia cardiorenal; Congestió Albuminuria; Enfermedad cardiorrenal; Congestión Background Albuminuria could potentially emerge as a novel marker of congestion in acute heart failure. However, the current evidence linking albuminuria and congestion in patients with congestive heart failure (CHF) remains somewhat scarce. This study aimed to evaluate the prevalence of albuminuria in a cohort of patients with CHF, identify the independent factors associated with albuminuria and analyse the correlation with different congestion parameters. Methods This is a subanalysis of the Spanish Cardiorenal Registry, in which we enrolled 864 outpatients with heart failure and a value of urinary albumin:creatinine ratio (UACR) at the first visit. Results The median age was 74 years, 549 (63.5%) were male and 438 (50.7%) had a reduced left ventricular ejection fraction. A total of 350 patients (40.5%) had albuminuria. Among these patients, 386 (33.1%) had a UACR of 30–300 mg/g and 64 (7.4%) had a UACR >300 mg/g. In order of importance, the independent variables associated with higher UACR were estimated glomerular filtration rate determined by the Chronic Kidney Disease Epidemiology Collaboration equation (R2 = 57.6%), systolic blood pressure (R2 = 21.1%), previous furosemide equivalent dose (FED; R2 = 7.5%), antigen carbohydrate 125 (CA125; R2 = 6.1%), diabetes mellitus (R2 = 5.6%) and oedema (R2 = 1.9%). The combined influence of oedema, elevated CA125 levels and the FED accounted for 15.5% of the model's variability. Conclusions In patients with chronic stable heart failure, the prevalence of albuminuria is high. The risk factors of albuminuria in this population are chronic kidney disease and hypertension. Congestion parameters are also associated with increased albuminuria. We have received funding to produce this article from Astra Zeneca. http://hdl.handle.net/11351/11571 Insuficiència renal crònica Insuficiència cardíaca congestiva Albuminúria - Factors de risc DISEASES::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Urological Manifestations::Proteinuria::Albuminuria ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors DISEASES::Male Urogenital Diseases::Urologic Diseases::Kidney Diseases::Renal Insufficiency::Renal Insufficiency, Chronic DISEASES::Cardiovascular Diseases::Heart Diseases::Heart Failure ENFERMEDADES::afecciones patológicas, signos y síntomas::signos y síntomas::manifestaciones urológicas::proteinuria::albuminuria TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::métodos epidemiológicos::estadística como asunto::probabilidad::riesgo::factores de riesgo ENFERMEDADES::enfermedades urogenitales masculinas::enfermedades urológicas::enfermedades renales::insuficiencia renal::insuficiencia renal crónica ENFERMEDADES::enfermedades cardiovasculares::enfermedades cardíacas::insuficiencia cardíaca Congestion as a crucial factor determining albuminuria in patients with cardiorenal disease