2026-04-17T02:40:03Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/114922025-10-24T10:36:18Zcom_2072_378070com_2072_378040col_2072_378092

00925njm 22002777a 4500 dc PEREZ, ALICIA author Acevedo-Nuevo, María author Padilla Martínez, María author Gomez Brey, Aroa author Zapata, Luis author Barber, Maria author 2024-05-23T09:34:50Z 2024-05-23T09:34:50Z 2024-04-12 Deceased organ donation; Devastating brain injury; Transplantation Donación de órganos de fallecidos; Lesión cerebral devastadora; Trasplante Donació d'òrgans de difunts; Lesió cerebral devastadora; Trasplantament Intensive Care to facilitate Organ Donation (ICOD) consists of the initiation or continuation of intensive care measures in patients with a devastating brain injury (DBI) in whom curative treatment is deemed futile and death by neurological criteria (DNC) is foreseen, to incorporate organ donation into their end-of-life plans. In this study we evaluate the outcomes of patients subject to ICOD and identify radiological and clinical factors associated with progression to DNC. In this first prospective multicenter study we tested by multivariate regression the association of clinical and radiological severity features with progression to DNC. Of the 194 patients, 144 (74.2%) patients fulfilled DNC after a median of 25 h (95% IQR: 17–44) from ICOD onset. Two patients (1%) shifted from ICOD to curative treatment, both were alive at discharge. Factors associated with progression to DNC included: age below 70 years, clinical score consistent with severe brain injury, instability, intracranial hemorrhage, midline shift ≥5 mm and certain types of brain herniation. Overall 151 (77.8%) patients progressed to organ donation. Based on these results, we conclude that ICOD is a beneficial and efficient practice that can contribute to the pool of deceased donors. http://hdl.handle.net/11351/11492 Mort cerebral Malalts en estat crític Trasplantació d'òrgans, teixits, etc. Avaluació de resultats (Assistència sanitària) HEALTH CARE::Health Care Facilities, Manpower, and Services::Health Services::Tissue and Organ Procurement DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Brain Death ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Patient Care::Critical Care ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Prognosis::Treatment Outcome ATENCIÓN DE SALUD::instalaciones, servicios y personal de asistencia sanitaria::servicios de salud::obtención de tejidos y órganos ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::muerte cerebral TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::asistencia al paciente::asistencia del enfermo crítico TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronóstico::resultado del tratamiento Assessing Outcomes of Patients Subject to Intensive Care to Facilitate Organ Donation: A Spanish Multicenter Prospective Study