2026-04-17T08:04:32Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/114582025-10-24T10:44:07Zcom_2072_378070com_2072_378040col_2072_378092

2025-10-24T10:44:07Z urn:hdl:11351/11458 Renal Disease in Metabolic Syndrome: the Hidden Role of Intrarenal Ischemia Rodríguez-Rodríguez, Rosa Hornum, Mads Rodríguez-Rodríguez, Ana Elena Bevc, Sebastjan Trevisani, Francesco Fernández-Juárez, Gema Moreso, Francesc Obesitat Ronyons - Malalties - Fisiologia patològica Síndrome metabòlica DISEASES::Nutritional and Metabolic Diseases::Metabolic Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Metabolic Syndrome DISEASES::Male Urogenital Diseases::Urologic Diseases::Kidney Diseases DISEASES::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::Obesity ENFERMEDADES::enfermedades nutricionales y metabólicas::enfermedades metabólicas::enfermedades nutricionales y metabólicas::enfermedades metabólicas::síndrome metabólico ENFERMEDADES::enfermedades urogenitales masculinas::enfermedades urológicas::enfermedades renales ENFERMEDADES::enfermedades nutricionales y metabólicas::trastornos nutricionales::hipernutrición::obesidad Diabetic nephropathy; Metabolic syndrome; Vascular disease Nefropatía diabética; Síndrome metabólico; Enfermedad vascular Nefropatia diabètica; Síndrome metabòlica; Malaltia vascular Introduction The pathogenesis of renal disease in obesity and metabolic syndrome (MS) is mostly unknown. This is in part because of the limited information about renal morphological changes in these conditions. We evaluated renal histology in subjects with MS and those without MS, who are participants in the European Nephrectomy Biobank (ENBiBA) project. Methods MS was defined with at least 3 of the following criteria: (i) body mass index (BMI) ≥27 kg/m2; (ii) prediabetes: fasting glucose of 100–125 mg/dl or HbA1c >5.7%; (iii) systolic or diastolic blood pressure >140/90 mm Hg or the use of medications; and (iv) triglycerides >150 mg/dl or high-density lipoprotein cholesterol <40 (in men) or 50 mg/dl (in women). The absence of these criteria defined patients without MS. Exclusion criteria were diabetes or known causes of renal disease. Results A total of 157 cases were evaluated: 49 without and 108 with MS. Those with MS were older (54 ± 16 vs. 66 ± 11, P < 0.0001), had more prevalent chronic kidney disease (CKD, estimated glomerular filtration rate [eGFR] <60 ml/min): 24% (23%) versus 4% (8%) (P = 0.02), and had higher albumin-to-creatinine ratio (10 [4–68] vs. 4.45 [0–27], P = 0.05) than those without MS. Global sclerosis (3% [1–7] vs. 7% [3–13], P < 0.0001), nodular sclerosis, mesangial expansion, glomerulomegaly; moderate + severe hyalinosis, and arteriosclerosis were more frequent in those with MS than in those without (88 [82] vs. 29 [59]; 83 [77] vs. 30 [61]; P < 0.05). These vascular changes were independent of differences in age. Conclusion In MS, ischemic renal disease may play a role in renal disease. In addition, some patients may develop lesions compatible with diabetic nephropathy such as increased mesangial expansion and nodular sclerosis. Further analyses are needed to study the consequences of the pandemic of obesity on renal health. 2025-10-24T10:44:07Z 2025-10-24T10:44:07Z 2024-05-15T06:56:16Z 2024-05-15T06:56:16Z 2024-02-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/11351/11458 Kidney International Reports;9(5) https://doi.org/10.1016/j.ekir.2024.02.1403 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess Elsevier Scientia