2026-04-17T06:31:52Zhttps://recercat.cat/oai/requestoai:recercat.cat:11351/113952025-10-24T10:37:51Zcom_2072_378070com_2072_378040col_2072_378092
RECERCAT
author
Timmermann , Beate
author
Alapetite, Claire
author
Dieckmann, Karin
author
Kortmann, Rolf-Dieter
author
Lassen-Ramshad, Yasmin
author
Maduro, John
author
Ramos Albiac, Monica
2025-10-24T10:37:51Z
2025-10-24T10:37:51Z
2024-04-30T09:59:58Z2024-04-30T09:59:58Z2024-03-14
http://hdl.handle.net/11351/11395
Atypical teratoid rhabdoid tumor; Children; RadiotherapyTumor rabdoide teratoide atípic; Nens; RadioteràpiaTumor rabdoide teratoideo atípico; Niños; RadioterapiaBackground and purpose
Treatment of patients with atypical teratoid/rhabdoid (AT/RT) is challenging, especially when very young (below the age of three years). Radiotherapy (RT) is part of a complex trimodality therapy. The purpose of this guideline is to provide appropriate recommendations for RT in the clinical management of patients not enrolled in clinical trials.
Materials and methods
Nine European experts were nominated to form a European Society for Radiotherapy and Oncology (ESTRO) guideline committee. A systematic literature search was conducted in PubMed/MEDLINE and Web of Science. They discussed and analyzed the evidence concerning the role of RT in the clinical management of AT/RT.
Results
Recommendations on diagnostic imaging, therapeutic principles, RT considerations regarding timing, dose, techniques, target volume definitions, dose constraints of radiation-sensitive organs at risk, concomitant chemotherapy, and follow-up were considered. Treating children with AT/RT within the framework of prospective trials or prospective registries is of utmost importance.
Conclusion
The present guideline summarizes the evidence and clinical-based recommendations for RT in patients with AT/RT. Prospective clinical trials and international, large registries evaluating modern treatment approaches will contribute to a better understanding of the best treatment for these children in future.
Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess
Cervell - Càncer - Radioteràpia
Sistema nerviós central - Càncer - Radioteràpia
Infants
DISEASES::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Complex and Mixed::Rhabdoid Tumor
Other subheadings::Other subheadings::Other subheadings::/radiotherapy
DISEASES::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Germ Cell and Embryonal::Teratoma
DISEASES::Neoplasms::Neoplasms by Site::Nervous System Neoplasms::Central Nervous System Neoplasms::Brain Neoplasms
NAMED GROUPS::Persons::Age Groups::Child
ENFERMEDADES::neoplasias::neoplasias por tipo histológico::neoplasias complejas y mixtas::tumor rabdoide
Otros calificadores::Otros calificadores::Otros calificadores::/radioterapia
ENFERMEDADES::neoplasias::neoplasias por tipo histológico::neoplasias de células germinales y embrionarias::teratoma
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias del sistema nervioso::neoplasias del sistema nervioso central::neoplasias cerebrales
DENOMINACIONES DE GRUPOS::personas::Grupos de Edad::niño
ESTRO-SIOPE guideline: Clinical management of radiotherapy in atypical teratoid/rhabdoid tumors (AT/RTs)
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion