2026-04-17T11:26:45Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/113952025-10-24T10:37:51Zcom_2072_378070com_2072_378040col_2072_378092

00925njm 22002777a 4500 dc Timmermann , Beate author Alapetite, Claire author Dieckmann, Karin author Kortmann, Rolf-Dieter author Lassen-Ramshad, Yasmin author Maduro, John author Ramos Albiac, Monica author 2024-04-30T09:59:58Z 2024-04-30T09:59:58Z 2024-03-14 Atypical teratoid rhabdoid tumor; Children; Radiotherapy Tumor rabdoide teratoide atípic; Nens; Radioteràpia Tumor rabdoide teratoideo atípico; Niños; Radioterapia Background and purpose Treatment of patients with atypical teratoid/rhabdoid (AT/RT) is challenging, especially when very young (below the age of three years). Radiotherapy (RT) is part of a complex trimodality therapy. The purpose of this guideline is to provide appropriate recommendations for RT in the clinical management of patients not enrolled in clinical trials. Materials and methods Nine European experts were nominated to form a European Society for Radiotherapy and Oncology (ESTRO) guideline committee. A systematic literature search was conducted in PubMed/MEDLINE and Web of Science. They discussed and analyzed the evidence concerning the role of RT in the clinical management of AT/RT. Results Recommendations on diagnostic imaging, therapeutic principles, RT considerations regarding timing, dose, techniques, target volume definitions, dose constraints of radiation-sensitive organs at risk, concomitant chemotherapy, and follow-up were considered. Treating children with AT/RT within the framework of prospective trials or prospective registries is of utmost importance. Conclusion The present guideline summarizes the evidence and clinical-based recommendations for RT in patients with AT/RT. Prospective clinical trials and international, large registries evaluating modern treatment approaches will contribute to a better understanding of the best treatment for these children in future. http://hdl.handle.net/11351/11395 Cervell - Càncer - Radioteràpia Sistema nerviós central - Càncer - Radioteràpia Infants DISEASES::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Complex and Mixed::Rhabdoid Tumor Other subheadings::Other subheadings::Other subheadings::/radiotherapy DISEASES::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Germ Cell and Embryonal::Teratoma DISEASES::Neoplasms::Neoplasms by Site::Nervous System Neoplasms::Central Nervous System Neoplasms::Brain Neoplasms NAMED GROUPS::Persons::Age Groups::Child ENFERMEDADES::neoplasias::neoplasias por tipo histológico::neoplasias complejas y mixtas::tumor rabdoide Otros calificadores::Otros calificadores::Otros calificadores::/radioterapia ENFERMEDADES::neoplasias::neoplasias por tipo histológico::neoplasias de células germinales y embrionarias::teratoma ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias del sistema nervioso::neoplasias del sistema nervioso central::neoplasias cerebrales DENOMINACIONES DE GRUPOS::personas::Grupos de Edad::niño ESTRO-SIOPE guideline: Clinical management of radiotherapy in atypical teratoid/rhabdoid tumors (AT/RTs)