2026-04-17T12:00:48Zhttps://recercat.cat/oai/requestoai:recercat.cat:11351/113942025-10-24T10:42:04Zcom_2072_378070com_2072_378040col_2072_378092
RECERCAT
author
Iba, Toshiaki
author
Maier, Cheryl
author
Helms, Julie
author
Thachil, Jecko
author
Levy, Jerrold
author
Ferrer, Ricard
2025-10-24T10:42:04Z
2025-10-24T10:42:04Z
2024-04-30T09:38:51Z2024-04-30T09:38:51Z2024-04-24
http://hdl.handle.net/11351/11394
Endothelial cell; Glycocalyx; SepsisCélula endotelial; Glicocálix; SepsisCèl·lula endotelial; Glicocàlix; SèpsiaMaintaining tissue perfusion in sepsis depends on vascular integrity provided by the endothelial glycocalyx, the critical layer covering the luminal surface of blood vessels. The glycocalyx is composed of proteoglycans, glycosaminoglycans, and functional plasma proteins that are critical for antithrombogenicity, regulating tone, controlling permeability, and reducing endothelial interactions with leukocytes and platelets. Degradation of the glycocalyx in sepsis is substantial due to thromboinflammation, and treatments for sepsis and septic shock may exacerbate endotheliopathy via additional glycocalyx injury. As a result, therapeutic strategies aimed at preserving glycocalyx integrity should be considered, including modifications in fluid volume resuscitation, minimizing catecholamine use, controlling hyperglycemia, and potential use of corticosteroids and anticoagulants. In this review, we explore treatment strategies aligned with the recommendations outlined in the Surviving Sepsis Campaign Guidelines 2021 with a special emphasis on evidence regarding glycocalyx protection.This work was supported in part by a Grant-in-Aid for Special Research in Subsidies for ordinary expenses of private schools from The Promotion and Mutual Aid Corporation for Private Schools of Japan.
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess
Septicèmia - Tractament
Cèl·lules epitelials
Membranes cel·lulars
ANATOMY::Cells::Epithelial Cells::Endothelial Cells
ANATOMY::Cells::Cellular Structures::Cell Membrane::Cell Membrane Structures::Glycocalyx
DISEASES::Bacterial Infections and Mycoses::Infection::Sepsis
Other subheadings::Other subheadings::/therapy
ANATOMÍA::células::células epiteliales::células endoteliales
ANATOMÍA::células::estructuras celulares::membrana celular::estructuras de la membrana celular::glicocálix
ENFERMEDADES::infecciones bacterianas y micosis::infección::sepsis
Otros calificadores::Otros calificadores::/terapia
Managing sepsis and septic shock in an endothelial glycocalyx-friendly way: from the viewpoint of surviving sepsis campaign guidelines
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion