2026-04-14T02:45:04Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/113942025-10-24T10:42:04Zcom_2072_378070com_2072_378040col_2072_378092

00925njm 22002777a 4500 dc Iba, Toshiaki author Maier, Cheryl author Helms, Julie author Thachil, Jecko author Levy, Jerrold author Ferrer, Ricard author 2024-04-30T09:38:51Z 2024-04-30T09:38:51Z 2024-04-24 Endothelial cell; Glycocalyx; Sepsis Célula endotelial; Glicocálix; Sepsis Cèl·lula endotelial; Glicocàlix; Sèpsia Maintaining tissue perfusion in sepsis depends on vascular integrity provided by the endothelial glycocalyx, the critical layer covering the luminal surface of blood vessels. The glycocalyx is composed of proteoglycans, glycosaminoglycans, and functional plasma proteins that are critical for antithrombogenicity, regulating tone, controlling permeability, and reducing endothelial interactions with leukocytes and platelets. Degradation of the glycocalyx in sepsis is substantial due to thromboinflammation, and treatments for sepsis and septic shock may exacerbate endotheliopathy via additional glycocalyx injury. As a result, therapeutic strategies aimed at preserving glycocalyx integrity should be considered, including modifications in fluid volume resuscitation, minimizing catecholamine use, controlling hyperglycemia, and potential use of corticosteroids and anticoagulants. In this review, we explore treatment strategies aligned with the recommendations outlined in the Surviving Sepsis Campaign Guidelines 2021 with a special emphasis on evidence regarding glycocalyx protection. This work was supported in part by a Grant-in-Aid for Special Research in Subsidies for ordinary expenses of private schools from The Promotion and Mutual Aid Corporation for Private Schools of Japan. http://hdl.handle.net/11351/11394 Septicèmia - Tractament Cèl·lules epitelials Membranes cel·lulars ANATOMY::Cells::Epithelial Cells::Endothelial Cells ANATOMY::Cells::Cellular Structures::Cell Membrane::Cell Membrane Structures::Glycocalyx DISEASES::Bacterial Infections and Mycoses::Infection::Sepsis Other subheadings::Other subheadings::/therapy ANATOMÍA::células::células epiteliales::células endoteliales ANATOMÍA::células::estructuras celulares::membrana celular::estructuras de la membrana celular::glicocálix ENFERMEDADES::infecciones bacterianas y micosis::infección::sepsis Otros calificadores::Otros calificadores::/terapia Managing sepsis and septic shock in an endothelial glycocalyx-friendly way: from the viewpoint of surviving sepsis campaign guidelines