2026-04-17T05:31:13Zhttps://recercat.cat/oai/requestoai:recercat.cat:11351/112832025-10-24T10:25:52Zcom_2072_378070com_2072_378040col_2072_378092
RECERCAT
author
Carrillo-Bosch, Laura
author
Barba, Ignasi
author
Seoane, Joan
2025-10-24T10:25:52Z
2025-10-24T10:25:52Z
2024-04-05T07:06:27Z2024-04-05T07:06:27Z2024-03-08
http://hdl.handle.net/11351/11283
Warburg effect; Aerobic glycolysis; Tumor metabolismEfecto Warburg; Glucólisis aeróbica; Metabolismo tumoralEfecte Warburg; Glucòlisi aeròbica; Metabolisme tumoralThe Warburg effect, characterized by the preferential conversion of glucose to lactate even in the presence of oxygen and functional mitochondria, is a prominent metabolic hallmark of cancer cells and has emerged as a promising therapeutic target for cancer therapy. Elevated lactate levels and acidic pH within the tumor microenvironment (TME) resulting from glycolytic profoundly impact various cellular populations, including macrophage reprogramming and impairment of T-cell functionality. Altogether, the Warburg effect has been shown to promote tumor progression and immunosuppression through multiple mechanisms. This review provides an overview of the current understanding of the Warburg effect in cancer and its implications. We summarize recent pharmacological strategies aimed at targeting glycolytic enzymes, highlighting the challenges encountered in achieving therapeutic efficacy. Additionally, we examine the utility of the Warburg effect as an early diagnostic tool. Finally, we discuss the multifaceted roles of lactate within the TME, emphasizing its potential as a therapeutic target to disrupt metabolic interactions between tumor and immune cells, thereby enhancing anti-tumor immunity.The study was undertaken with the support of the Fundación Asociación Española contra el Cáncer (AECC), the ISCIII, FIS (PI22/00130), BBVA (CAIMI), and Cellex Foundation.
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess
Càncer
Mitocondris
Glucòlisi
Cèl·lules canceroses
Metabolisme
DISEASES::Neoplasms
Other subheadings::Other subheadings::Other subheadings::/metabolism
ANATOMY::Cells::Cellular Structures::Intracellular Space::Cytoplasm::Cytoplasmic Structures::Organelles::Mitochondria
PHENOMENA AND PROCESSES::Cell Physiological Phenomena::Cellular Microenvironment::Tumor Microenvironment
PHENOMENA AND PROCESSES::Metabolism::Carbohydrate Metabolism::Metabolism::Metabolism::Glycolysis
ENFERMEDADES::neoplasias
Otros calificadores::Otros calificadores::Otros calificadores::/metabolismo
ANATOMÍA::células::estructuras celulares::espacio intracelular::citoplasma::estructuras citoplasmáticas::orgánulos::mitocondrias
FENÓMENOS Y PROCESOS::fenómenos fisiológicos celulares::microambiente celular::microambiente tumoral
FENÓMENOS Y PROCESOS::metabolismo::metabolismo de los hidratos de carbono::metabolismo::metabolismo::glicólisis
Targeting the Warburg Effect in Cancer: Where Do We Stand?
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion