2026-04-19T11:04:01Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/112832025-10-24T10:25:52Zcom_2072_378070com_2072_378040col_2072_378092

00925njm 22002777a 4500 dc Carrillo-Bosch, Laura author Barba, Ignasi author Seoane, Joan author 2024-04-05T07:06:27Z 2024-04-05T07:06:27Z 2024-03-08 Warburg effect; Aerobic glycolysis; Tumor metabolism Efecto Warburg; Glucólisis aeróbica; Metabolismo tumoral Efecte Warburg; Glucòlisi aeròbica; Metabolisme tumoral The Warburg effect, characterized by the preferential conversion of glucose to lactate even in the presence of oxygen and functional mitochondria, is a prominent metabolic hallmark of cancer cells and has emerged as a promising therapeutic target for cancer therapy. Elevated lactate levels and acidic pH within the tumor microenvironment (TME) resulting from glycolytic profoundly impact various cellular populations, including macrophage reprogramming and impairment of T-cell functionality. Altogether, the Warburg effect has been shown to promote tumor progression and immunosuppression through multiple mechanisms. This review provides an overview of the current understanding of the Warburg effect in cancer and its implications. We summarize recent pharmacological strategies aimed at targeting glycolytic enzymes, highlighting the challenges encountered in achieving therapeutic efficacy. Additionally, we examine the utility of the Warburg effect as an early diagnostic tool. Finally, we discuss the multifaceted roles of lactate within the TME, emphasizing its potential as a therapeutic target to disrupt metabolic interactions between tumor and immune cells, thereby enhancing anti-tumor immunity. The study was undertaken with the support of the Fundación Asociación Española contra el Cáncer (AECC), the ISCIII, FIS (PI22/00130), BBVA (CAIMI), and Cellex Foundation. http://hdl.handle.net/11351/11283 Càncer Mitocondris Glucòlisi Cèl·lules canceroses Metabolisme DISEASES::Neoplasms Other subheadings::Other subheadings::Other subheadings::/metabolism ANATOMY::Cells::Cellular Structures::Intracellular Space::Cytoplasm::Cytoplasmic Structures::Organelles::Mitochondria PHENOMENA AND PROCESSES::Cell Physiological Phenomena::Cellular Microenvironment::Tumor Microenvironment PHENOMENA AND PROCESSES::Metabolism::Carbohydrate Metabolism::Metabolism::Metabolism::Glycolysis ENFERMEDADES::neoplasias Otros calificadores::Otros calificadores::Otros calificadores::/metabolismo ANATOMÍA::células::estructuras celulares::espacio intracelular::citoplasma::estructuras citoplasmáticas::orgánulos::mitocondrias FENÓMENOS Y PROCESOS::fenómenos fisiológicos celulares::microambiente celular::microambiente tumoral FENÓMENOS Y PROCESOS::metabolismo::metabolismo de los hidratos de carbono::metabolismo::metabolismo::glicólisis Targeting the Warburg Effect in Cancer: Where Do We Stand?