2026-04-13T01:08:26Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/112442025-10-24T10:59:30Zcom_2072_451665com_2072_378040col_2072_451666

2025-10-24T10:59:30Z urn:hdl:11351/11244 Unexpected Durable Complete Response With Anti–PD-L1 Blockade in Metastatic Undifferentiated Pleomorphic Sarcoma: A Case Report With Host and Tumor Biomarker Analysis Pesántez, David Angelats, Laura Sirico, Marianna Victoria Ruiz, Iván Indacochea Cusirramos, Alberto Sanfeliu Torres, Esther Marcadors bioquímics Teixits - Tumors Immunologia CHEMICALS AND DRUGS::Biological Factors::Biomarkers::Biomarkers, Tumor DISEASES::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Connective and Soft Tissue::Sarcoma ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Biological Therapy::Immunomodulation::Immunotherapy CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Intercellular Signaling Peptides and Proteins::B7 Antigens::B7-H1 Antigen Other subheadings::Other subheadings::Other subheadings::/antagonists & inhibitors COMPUESTOS QUÍMICOS Y DROGAS::factores biológicos::biomarcadores::marcadores tumorales ENFERMEDADES::neoplasias::neoplasias por tipo histológico::neoplasias de tejido conjuntivo y de tejidos blandos::sarcoma TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapia biológica::inmunomodulación::inmunoterapia COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::péptidos y proteínas de señalización intercelular::antígenos B7::antígeno B7-H1 Otros calificadores::Otros calificadores::Otros calificadores::/antagonistas & inhibidores Soft-tissue sarcomes; Biomarker Analysis; Undifferentiated Pleomorphic Sarcoma Sarcomas de tejidos blandos; Análisis de Biomarcadores; Sarcoma pleomórfico indiferenciado Sarcomes de teixit tou; Anàlisi de biomarcadors; Sarcoma pleomòrfic indiferenciat Soft-tissue sarcomas (STSs) are a heterogeneous group of tumors, representing approximately 1% of adult malignancies.1 Within STSs, undifferentiated pleomorphic sarcomas (UPSs) are one of the most frequent subgroups (5%-15%).2 Treatment options of advanced UPS remain limited, and the prognosis of patients with metastatic disease is poor, with a median survival of approximately 12 months.3 UPS is characterized by a high level of genomic instability, as indicated by its complex karyotype with low tumor mutational burden (TMB) but high copy number alterations.4,5 This feature can be theoretically associated with higher immunogenicity because of a potential increase in neoantigen formation.6 For this reason, there is potential role for immunotherapy with immune checkpoint inhibitors (ICIs) in this subset of patients.7 Here, we report the case of a patient with metastatic UPS of the chest wall successfully treated with an anti–PD-L1 ICI at the Clinical Trial Unit of the Hospital Clinic of Barcelona (HCB), who experienced an exceptionally prolonged complete response (CR). Because of the lack of biomarkers for the correct identification of patients with UPS benefiting the most from ICIs, an extensive clinicopathological and molecular profiling was performed to explain this uncommon response F.S. received a European Society for Medical Oncology (ESMO) Fellowship—Translational and the 2021 BBVA Foundation/Hospital Clinic of Barcelona Joan Rodes´ —Jose Baselga Advanced Research Contract in Oncology. F.S. is also recipient of a Rio Hortega 2022 Contract (Ministry of Health, Spain). L.A. is recipient of a Rio Hortega 2020 Contract (Ministry of Health, Spain). F.B.-M. received the Ayuda Investigador AECC 2021 (INVES21943BRAS) from Fundacion´ cient´ıfica AECC. A.P. has received funding from Fundacion CRIS ´ contra el cancer PR_EX_2021-14, Ag ´ encia de Gest ` o d ´ ’Ajuts Universitaris i de Recerca 2021 SGR 01156, Fundacion Fero BECA ´ ONCOXXI21, Instituto de Salud Carlos III PI22/01017, Asociacion´ Cancer de Mama Metast ´ asico IV Premios M. Chiara Giorgetti, Breast ´ Cancer Research Foundation BCRF-23-198, and RESCUER, funded by European Union’s Horizon 2020 Research and Innovation Program under Grant Agreement No. 847912. 2025-10-24T10:59:30Z 2025-10-24T10:59:30Z 2024-03-26T08:12:20Z 2024-03-26T08:12:20Z 2023-10-19 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/11351/11244 JCO Precision Oncology;7 https://doi.org/10.1200/PO.23.00051 info:eu-repo/grantAgreement/EC/H2020/847912 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess American Society of Clinical Oncology Scientia