2026-04-14T07:04:51Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/111952025-10-24T08:27:56Zcom_2072_451660com_2072_378040col_2072_451662

00925njm 22002777a 4500 dc Ariza, Mar author NAUTILUS-Project Collaborative Group author Barrué subirana, Cristian author Cano Marco, Neus author Segura, Barbara author Bejar, Javier author Garolera, Maite author 2024-03-14T13:55:28Z 2024-03-14T13:55:28Z 2024-01-29 Post-COVID-19 condition; Mental speed processing; Logistic regression Condición post-COVID-19; Procesamiento de velocidad mental; Regresión logística Estat post-COVID-19; Processament de velocitat mental; Regressió logística The risk factors for post-COVID-19 cognitive impairment have been poorly described. This study aimed to identify the sociodemographic, clinical, and lifestyle characteristics that characterize a group of post-COVID-19 condition (PCC) participants with neuropsychological impairment. The study sample included 426 participants with PCC who underwent a neurobehavioral evaluation. We selected seven mental speed processing and executive function variables to obtain a data-driven partition. Clustering algorithms were applied, including K-means, bisecting K-means, and Gaussian mixture models. Different machine learning algorithms were then used to obtain a classifier able to separate the two clusters according to the demographic, clinical, emotional, and lifestyle variables, including logistic regression with least absolute shrinkage and selection operator (LASSO) (L1) and Ridge (L2) regularization, support vector machines (linear/quadratic/radial basis function kernels), and decision tree ensembles (random forest/gradient boosting trees). All clustering quality measures were in agreement in detecting only two clusters in the data based solely on cognitive performance. A model with four variables (cognitive reserve, depressive symptoms, obesity, and change in work situation) obtained with logistic regression with LASSO regularization was able to classify between good and poor cognitive performers with an accuracy and a weighted averaged precision of 72%, a recall of 73%, and an area under the curve of 0.72. PCC individuals with a lower cognitive reserve, more depressive symptoms, obesity, and a change in employment status were at greater risk for poor performance on tasks requiring mental processing speed and executive function. Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. This research was supported by the European Archives of Psychiatry and Clinical Neuroscience Agency for Management of University and Research Grants (AGAUR) from the Generalitat de Catalunya (Pandemies, 2020PANDE00053), the La Marató de TV3 Foundation (202111–30-31–32), the Ministerio de Ciencia e Innovación (TED2021-130409B-C55). http://hdl.handle.net/11351/11195 COVID-19 (Malaltia) DISEASES::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections::Severe Acute Respiratory Syndrome DISEASES::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes PSYCHIATRY AND PSYCHOLOGY::Psychological Phenomena::Mental Processes ENFERMEDADES::afecciones patológicas, signos y síntomas::procesos patológicos::atributos de la enfermedad ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus PSIQUIATRÍA Y PSICOLOGÍA::fenómenos psicológicos::procesos mentales Cognitive reserve, depressive symptoms, obesity, and change in employment status predict mental processing speed and executive function after COVID-19