2026-04-17T04:21:44Zhttps://recercat.cat/oai/requestoai:recercat.cat:11351/111842025-10-24T10:56:14Zcom_2072_451667com_2072_378040col_2072_451668
RECERCAT
author
Terceño, Mikel
author
Remollo Friedemann, Sebastian
author
Silva, Yolanda
author
Werner, Mariano
author
Vera Monge, Víctor Augusto
author
Serena, Joaquín
author
Castaño Duque, Carlos
author
Bashir Viturro, Saima
2025-10-24T10:56:14Z
2025-10-24T10:56:14Z
2024-03-12T12:18:52Z2024-03-12T12:18:52Z2021-02-18
http://hdl.handle.net/11351/11184
Aneurisme intracranial; Estatines; AspirinaAneurismo intracraneal; Estatinas; AspirinaIntracranial aneurysm; Statins; AspirinBackground: Acetylsalicylic acid (ASA) and statins have been identified as potentially reducing the risk of intracranial aneurysms (IA) rupture. We aim to determine the effect of this drugs on the risk of rupture of IA.
Patients and methods: We performed a retrospective cohort study from a prospective database of patients with IA treated in our institution between January 2013 and December 2018. Demographics, previous oral treatments, presence of multiple aneurysms, size of aneurysm, lobulation, location and morphology of the aneurysms were recorded. Patients were dichotomized as ruptured and unruptured IA.
Results: A total of 408 IA were treated, of which 283 (68.6%) were in women. The median age was 53, 194 (47.5%) were ruptured IA. 38 patients (9.3%) were receiving ASA and 84 (20.6%) were receiving statins at the moment of the IA diagnosis. In the multivariable regression analysis, ASA plus statin use and multiple aneurysms were independently associated with unruptured IA (OR 5.01, 95% CI, 1.37-18.33, P = 0.015 and OR 2.72, 95% CI 1.68-4.27, P<0.001, respectively). Whereas, lobulated wall aneurysm and PComA/AComA location were inversely and independently associated with unruptured IA condition (OR 0.34, 95% CI 0.21-0.55, P<0.001 and OR 0.37, 95% CI 0.23-0.60, P<0.001, respectively). However, ASA and statins in monotherapy were not independently associated with unruptured IA condition.
Conclusions: In our study population ASA plus statins treatment is independently associated with unruptured IA. Larger and prospective studies are required to explore this potential protective effect against IA rupture.
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess
Aneurismes cerebrals - Prevenció
Estatines (Medicaments cardiovasculars)
Aspirina
CHEMICALS AND DRUGS::Organic Chemicals::Hydrocarbons::Hydrocarbons, Cyclic::Hydrocarbons, Aromatic::Benzene Derivatives::Phenols::Hydroxybenzoates::Salicylates::Aspirin
CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Antimetabolites::Hypolipidemic Agents::Anticholesteremic Agents::Hydroxymethylglutaryl-CoA Reductase Inhibitors
DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders::Intracranial Arterial Diseases::Intracranial Aneurysm
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares::enfermedades arteriales intracraneales::aneurisma intracraneal
COMPUESTOS QUÍMICOS Y DROGAS::compuestos orgánicos::hidrocarburos::hidrocarburos cíclicos::hidrocarburos aromáticos::derivados del benceno::fenoles::hidroxibenzoatos::salicilatos::aspirina
COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::mecanismos moleculares de acción farmacológica::antimetabolitos::hipolipemiantes::anticolesterolemiantes::inhibidores de las hidroximetilglutaril-CoA reductasas
Effect of combined acetylsalicylic acid and statins treatment on intracranial aneurysm rupture
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion