2026-04-17T01:32:00Zhttps://recercat.cat/oai/requestoai:recercat.cat:11351/111202025-10-24T10:33:53Zcom_2072_378070com_2072_378040col_2072_378092
RECERCAT
author
Coloretti, Irene
author
Genovese, Andrea
author
Teixeira, Pedro J.
author
Cherian, Anusha
author
LANDONI, Giovanni
author
Ferrer, Ricard
2025-10-24T10:33:53Z
2025-10-24T10:33:53Z
2024-02-26T12:42:51Z2024-02-26T12:42:51Z2024-02-21
http://hdl.handle.net/11351/11120
Angiotensina II; Shock sèptic; VasopressorsAngiotensin II; Septic shock; VasopressorsAngiotensina II; Shock séptico; VasopresoresPatients with septic shock who experience refractory hypotension despite adequate fluid resuscitation and high-dose noradrenaline have high mortality rates. To improve outcomes, evidence-based guidelines recommend starting a second vasopressor, such as vasopressin, if noradrenaline doses exceed 0.5 µg/kg/min. Recently, promising results have been observed in treating refractory hypotension with angiotensin II, which has been shown to increase mean arterial pressure and has been associated with improved outcomes. This narrative review aims to provide an overview of the pathophysiology of the renin-angiotensin system and the role of endogenous angiotensin II in vasodilatory shock with a focus on how angiotensin II treatment impacts clinical outcomes and on identifying the population that may benefit most from its use.
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess
Xoc sèptic - Tractament
Hipotensió arterial
DISEASES::Bacterial Infections and Mycoses::Infection::Sepsis::Shock, Septic
Other subheadings::Other subheadings::Other subheadings::/drug therapy
DISEASES::Cardiovascular Diseases::Vascular Diseases::Hypotension
ENFERMEDADES::infecciones bacterianas y micosis::infección::sepsis::choque séptico
Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia
ENFERMEDADES::enfermedades cardiovasculares::enfermedades vasculares::hipotensión
Angiotensin ii therapy in refractory septic shock: which patient can benefit most? A narrative review
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion