2026-04-13T00:51:10Zhttps://recercat.cat/oai/requestoai:recercat.cat:11351/111152025-10-24T10:19:46Zcom_2072_378070com_2072_378040col_2072_378092
RECERCAT
author
Román Ivorra, Jose A
author
Trallero-Araguás, Ernesto
author
Lopez Lasanta, Maria America
author
Cebrián, Laura
author
Lojo, Leticia
author
López-Muñíz, Belén
2025-10-24T10:19:46Z
2025-10-24T10:19:46Z
2024-02-26T07:58:22Z2024-02-26T07:58:22Z2024-01
http://hdl.handle.net/11351/11115
Artritis reumatoide; Epidemiologia; Fibrosi pulmonarRheumatoid arthritis; Epidemiology; Pulmonary fibrosisArtritis reumatoide; Epidemiología; Fibrosis pulmonarObjectives Real-world data regarding rheumatoid arthritis (RA) and its association with interstitial lung disease (ILD) is still scarce. This study aimed to estimate the prevalence of RA and ILD in patients with RA (RAILD) in Spain, and to compare clinical characteristics of patients with RA with and without ILD using natural language processing (NLP) on electronic health records (EHR).
Methods Observational case–control, retrospective and multicentre study based on the secondary use of unstructured clinical data from patients with adult RA and RAILD from nine hospitals between 2014 and 2019. NLP was used to extract unstructured clinical information from EHR and standardise it into a SNOMED-CT terminology. Prevalence of RA and RAILD were calculated, and a descriptive analysis was performed. Characteristics between patients with RAILD and RA patients without ILD (RAnonILD) were compared.
Results From a source population of 3 176 165 patients and 64 241 683 EHRs, 13 958 patients with RA were identified. Of those, 5.1% patients additionally had ILD (RAILD). The overall age-adjusted prevalence of RA and RAILD were 0.53% and 0.02%, respectively. The most common ILD subtype was usual interstitial pneumonia (29.3%). When comparing RAILD versus RAnonILD patients, RAILD patients were older and had more comorbidities, notably concerning infections (33.6% vs 16.5%, p<0.001), malignancies (15.9% vs 8.5%, p<0.001) and cardiovascular disease (25.8% vs 13.9%, p<0.001) than RAnonILD. RAILD patients also had higher inflammatory burden reflected in more pharmacological prescriptions and higher inflammatory parameters and presented a higher in-hospital mortality with a higher risk of death (HR 2.32; 95% CI 1.59 to 2.81, p<0.001).
Conclusions We found an estimated age-adjusted prevalence of RA and RAILD by analysing real-world data through NLP. RAILD patients were more vulnerable at the time of inclusion with higher comorbidity and inflammatory burden than RAnonILD, which correlated with higher mortality.The RA-WILD study was fully supported by Bristol-Myers Squibb Company. Award/grant number not applicable.
Attribution-NonCommercial 4.0 International http://creativecommons.org/licenses/by-nc/4.0/ info:eu-repo/semantics/openAccess
Aprenentatge automàtic
Artritis reumatoide - Epidemiologia
Pulmons - Malalties - Epidemiologia
DISEASES::Respiratory Tract Diseases::Lung Diseases::Lung Diseases, Interstitial
DISEASES::Musculoskeletal Diseases::Joint Diseases::Arthritis::Arthritis, Rheumatoid
PHENOMENA AND PROCESSES::Mathematical Concepts::Algorithms::Artificial Intelligence::Machine Learning
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Prevalence
ENFERMEDADES::enfermedades respiratorias::enfermedades pulmonares::enfermedades pulmonares intersticiales
ENFERMEDADES::enfermedades musculoesqueléticas::artropatías::artritis::artritis reumatoide
FENÓMENOS Y PROCESOS::conceptos matemáticos::algoritmos::inteligencia artificial::aprendizaje automático
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::métodos epidemiológicos::recopilación de datos::estadísticas vitales::morbilidad::prevalencia
Prevalence and clinical characteristics of patients with rheumatoid arthritis with interstitial lung disease using unstructured healthcare data and machine learning
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion