2026-04-13T01:52:59Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/110902025-10-24T10:51:12Zcom_2072_451669com_2072_378040col_2072_451670

Impact of bread diet on intestinal dysbiosis and irritable bowel syndrome symptoms in quiescent ulcerative colitis: A pilot study Lluansí, Aleix Llirós, Marc Carreras-Torres, Robert Bahí, Anna Capdevila, Montserrat Feliu, Anna Vilà-Quintana, Laura Sàbat Mir, Míriam [Lluansí A, Llirós M, Carreras-Torres R, Bahí A, Capdevila M, Feliu A, Vilà-Quintana L] Grup de Malalties Digestives i Microbiota, Institut d'Investigació Biomèdica de Girona (IDIBGI), Salt, Spain. [Sàbat M] Grup de Malalties Digestives i Microbiota, Institut d'Investigació Biomèdica de Girona (IDIBGI), Salt, Spain. Departament de Gastroenterologia, Hospital de Santa Caterina, Salt, Spain Institut d'Assistència Sanitària Colitis ulcerosa Còlon irritable Pa DISEASES::Digestive System Diseases::Gastrointestinal Diseases::Intestinal Diseases::Colonic Diseases::Colonic Diseases, Functional::Irritable Bowel Syndrome PHENOMENA AND PROCESSES::Physiological Phenomena::Diet, Food, and Nutrition::Food::Bread DISEASES::Digestive System Diseases::Gastrointestinal Diseases::Gastroenteritis::Colitis::Colitis, Ulcerative ENFERMEDADES::enfermedades del sistema digestivo::enfermedades gastrointestinales::gastroenteritis::colitis::colitis ulcerosa ENFERMEDADES::enfermedades del sistema digestivo::enfermedades gastrointestinales::enfermedades intestinales::enfermedades del colon::enfermedades funcionales del colon::síndrome del colon irritable FENÓMENOS Y PROCESOS::fenómenos fisiológicos::dieta, alimentación y nutrición::alimentos::pan Mal de panxa; Pa; Síndrome de l'intestí irritable Dolor abdominal; Pan; Síndrome del intestino irritable Abdominal pain; Bread; Irritable bowel syndrome Gut microbiota may be involved in the presence of irritable bowel syndrome (IBS)-like symptomatology in ulcerative colitis (UC) patients in remission. Bread is an important source of dietary fiber, and a potential prebiotic. To assess the effect of a bread baked using traditional elaboration, in comparison with using modern elaboration procedures, in changing the gut microbiota and relieving IBS-like symptoms in patients with quiescent ulcerative colitis. Thirty-one UC patients in remission with IBS-like symptoms were randomly assigned to a dietary intervention with 200 g/d of either treatment or control bread for 8 weeks. Clinical symptomatology was tested using questionnaires and inflammatory parameters. Changes in fecal microbiota composition were assessed by high-throughput sequencing of the 16S rRNA gene. A decrease in IBS-like symptomatology was observed after both the treatment and control bread interventions as reductions in IBS-Symptom Severity Score values (p-value < 0.001) and presence of abdominal pain (p-value < 0.001). The treatment bread suggestively reduced the Firmicutes/Bacteroidetes ratio (p-value = 0.058). In addition, the Firmicutes/Bacteroidetes ratio seemed to be associated with improving IBS-like symptoms as suggested by a slight decrease in patient without abdominal pain (p-value = 0.059). No statistically significant differential abundances were found at any taxonomic level. The intake of a bread baked using traditional elaboration decreased the Firmicutes/Bacteroidetes ratio, which seemed to be associated with improving IBS-like symptoms in quiescent ulcerative colitis patients. These findings suggest that the traditional bread elaboration has a potential prebiotic effect improving gut health (ClinicalTrials.gov ID number of study: NCT05656391). This study was funded by the Ministry of Economy, Industry and Competitiveness (MINECO) RETOS program (RTC-2017-6467-2). AL benefits from a grant included within the RTC-2017 program. The Instituto de Salud Carlos III supported RCT through the Miguel Servet Program CP21/00058. IE, NE, SDA and EC are employees of Elias-Boulanger, who have received funding from RTC-2017 program. The funders had no role in study design, data collection and analysis, decision to publish or manuscript preparation. 2024-02-20T13:10:31Z 2024-02-20T13:10:31Z 2024-02-16 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Lluansí A, Llirós M, Carreras-Torres R, Bahí A, Capdevila M, Feliu A, et al. Impact of bread diet on intestinal dysbiosis and irritable bowel syndrome symptoms in quiescent ulcerative colitis: A pilot study. PloS One 2024 Feb 16;19(2):e0297836. 1932-6203 https://hdl.handle.net/11351/11090 10.1371/journal.pone.0297836 38363772 http://hdl.handle.net/11351/11090 eng PLoS One;19(2) https://doi.org/10.1371/journal.pone.0297836 Attribution-ShareAlike 4.0 International http://creativecommons.org/licenses/by-sa/4.0/ info:eu-repo/semantics/openAccess application/pdf Public Library of Science Scientia