2026-04-17T02:27:49Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/110572024-06-06T08:40:50Zcom_2072_378070com_2072_378040col_2072_378092

00925njm 22002777a 4500 dc García Morales, Ariadna author Saoudi Gonzalez, Nadia author Ros, Javier author Baraibar, Iosune author Salvà, Francesc author R Castells, Marta author Alcaraz Soler, Adriana author Tabernero, Josep author Elez, Elena author 2024-02-16T08:34:17Z 2024-02-16T08:34:17Z 2024-01-18 Cetuximab; Colorectal cancer; Personalized treatment Cetuximab; Càncer de colorectal; Tracte personalitzat Cetuximab; Cáncer colorrectal; Trato personalizado Cetuximab, a chimeric IgG1 monoclonal antibody targeting the epidermal growth factor receptor (EGFR), has revolutionized personalized treatment of metastatic colorectal cancer (mCRC) patients. This review highlights the mechanism of action, characteristics, and optimal indications for cetuximab in mCRC. Cetuximab has emerged as a pivotal partner for novel therapies in specific molecular subgroups, including BRAF V600E, KRAS G12C, and HER2-altered mCRC. Combining cetuximab with immunotherapy and other targeted agents further expands the therapeutic landscape, offering renewed hope for mCRC patients who face the development of resistance to conventional therapies. Ongoing clinical trials have continued to uncover innovative cetuximab-based treatment strategies, promising a brighter future for mCRC patients. This review provides a comprehensive overview of cetuximab’s role and its evolving importance in personalized targeted therapy of mCRC patients, offering valuable insights into the evolving landscape of colorectal cancer treatment. http://hdl.handle.net/11351/11057 Còlon - Càncer - Tractament Recte - Càncer - Tractament Anticossos monoclonals - Ús terapèutic DISEASES::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms Other subheadings::Other subheadings::Other subheadings::/drug therapy CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Antibodies, Monoclonal Other subheadings::Other subheadings::/therapeutic use ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias del sistema digestivo::neoplasias gastrointestinales::neoplasias intestinales::neoplasias colorrectales Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas sanguíneas::inmunoproteínas::inmunoglobulinas::anticuerpos::anticuerpos monoclonales Otros calificadores::Otros calificadores::/uso terapéutico Cetuximab as a Key Partner in Personalized Targeted Therapy for Metastatic Colorectal Cancer