2026-04-19T19:18:19Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/107822025-10-24T10:28:54Zcom_2072_378070com_2072_378040col_2072_378092

00925njm 22002777a 4500 dc Nieto Ruiz, Adoración author Livovsky, Dan M. author Azpiroz, Fernando author 2024-01-09T08:12:53Z 2024-01-09T08:12:53Z 2023-12 Aversive conditioning; Cognitive intervention; Digestive wellbeing Condicionament aversiu; Intervenció cognitiva; Benestar digestiu Condicionamiento aversivo; Intervención cognitiva; Bienestar digestivo Background: Aversive conditioning weakens the gratifying value of a comfort meal. The aim was to determine the effect of a cognitive intervention to reverse aversive conditioning and restore hedonic postprandial response. Methods: This was a randomized, sham-controlled, single-blind, parallel study that was conducted on 12 healthy women (n = 6 in each group). The reward value of a comfort meal was measured on different days: at initial exposure, after aversive conditioning (administration of the same meal with a masked fat overload on the previous day) and after a cognitive intervention (disclosing the aversive conditioning paradigm in the test group vs. no explanation in the control group). The primary outcome, digestive wellbeing, was determined using graded scales at regular intervals before and after ingestion. Results: At initial exposure, the comfort meal produced a rewarding experience that was impaired using aversive conditioning; upon re-exposure to the original meal, the cognitive intervention increased meal wanting and liking; improved digestive wellbeing and mood; tended to reduce postprandial satiety, bloating/fullness; and abolished discomfort/pain, thereby restoring the hedonic value of the comfort meal. By contrast, sham intervention had no effects, and the postprandial sensations remained like the responses to the offending meal. Conclusion: In this proof-of-concept study, we demonstrate that in healthy women, a mild, short-term acquired aversion to a comfort meal can be reversed using a cognitive intervention. ClinicalTrials.gov ID: NCT05897411. Financial support was provided by the Ministerio de Ciencia e Innovación (grant PID2021-122295OB-I00, Agencia Estatal de Investigación). Ciberehd is financially backed by the Instituto de Salud Carlos III. http://hdl.handle.net/11351/10782 Cognició Aliments - Consum Aparell digestiu - Fisiologia PHENOMENA AND PROCESSES::Digestive System and Oral Physiological Phenomena::Digestive System Physiological Phenomena::Postprandial Period PSYCHIATRY AND PSYCHOLOGY::Psychological Phenomena::Mental Processes::Cognition PHENOMENA AND PROCESSES::Physiological Phenomena::Diet, Food, and Nutrition::Nutritional Physiological Phenomena::Eating FENÓMENOS Y PROCESOS::fenómenos fisiológicos orales y del sistema digestivo::fenómenos fisiológicos del sistema digestivo::período posprandial PSIQUIATRÍA Y PSICOLOGÍA::fenómenos psicológicos::procesos mentales::cognición FENÓMENOS Y PROCESOS::fenómenos fisiológicos::dieta, alimentación y nutrición::fenómenos fisiológicos nutricionales::ingestión de alimentos Reversal of Conditioned Food Aversion Using a Cognitive Intervention: A Sham-Controlled, Randomized, Parallel Study