2026-04-17T03:25:36Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/107422025-10-24T10:26:40Zcom_2072_378070com_2072_378040com_2072_451669col_2072_378092col_2072_451670

Staging Parkinson’s disease according to the MNCD classification correlates with caregiver burden de Deus Fonticoba, Teresa Cores Bartolomé, Carlos Feal Painceiras, María García Díaz, Iago Íñiguez-Alvarado, Maria Cristina Jose Manuel, Paz González Zúniga, Silvia de Jesús Cosgaya, Marina Garcia-Caldentey, Juan Legarda, Ines Hernández Vara, Jorge Cabo López, Iria Gonzalez-Aramburu, Isabel Ávila Rivera, María A. Gómez-Mayordomo, Víctor Nogueira, Víctor Dotor Garcia-Soto, Julio Borrué, Carmen Solano Vila, Berta Lopez Manzanares, Lydia Santos García, Diego Caballol, Nuria Parkinson, Malaltia de Cuidadors Qualitat de Vida DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Basal Ganglia Diseases::Parkinsonian Disorders::Parkinson Disease NAMED GROUPS::Persons::Caregivers ANTHROPOLOGY, EDUCATION, SOCIOLOGY, AND SOCIAL PHENOMENA::Social Sciences::Quality of Life ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::enfermedades de los ganglios basales::trastornos parkinsonianos::enfermedad de Parkinson DENOMINACIONES DE GRUPOS::personas::cuidadores de pacientes ANTROPOLOGÍA, EDUCACIÓN, SOCIOLOGÍA Y FENÓMENOS SOCIALES::ciencias sociales::calidad de vida Malaltia de Parkinson; Cuidador; Símptomes no motors Parkinson's disease; Caregiver; Non-motor symptoms Enfermedad de Parkinson; Cuidador; Síntomas no motores Background and objective: Recently, we demonstrated that staging Parkinson's disease (PD) with a novel simple classification called MNCD, based on four axes (motor, non-motor, cognition, and dependency) and five stages, correlated with disease severity and patients’ quality of life. Here, we analyzed the correlation of MNCD staging with PD caregiver's status. Patients and methods: Data from the baseline visit of PD patients and their principal caregiver recruited from 35 centers in Spain from the COPPADIS cohort from January 2016 to November 2017 were used to apply the MNCD total score (from 0 to 12) and MNCD stages (from 1 to 5) in this cross-sectional analysis. Caregivers completed the Zarit Caregiver Burden Inventory (ZCBI), Caregiver Strain Index (CSI), Beck Depression Inventory-II (BDI-II), PQ-10, and EUROHIS-QOL 8-item index (EUROHIS-QOL8). Results: Two hundred and twenty-four PD patients (63 ± 9.6 years old; 61.2% males) and their caregivers (58.5 ± 12.1 years old; 67.9% females) were included. The frequency of MNCD stages was 1, 7.6%; 2, 58.9%; 3, 31.3%; and 4–5, 2.2%. A more advanced MNCD stage was associated with a higher score on the ZCBI (p < .0001) and CSI (p < .0001), and a lower score on the PQ-10 (p = .001), but no significant differences were observed in the BDI-II (p = .310) and EUROHIS-QOL8 (p = .133). Moderate correlations were observed between the MNCD total score and the ZCBI (r = .496; p < .0001), CSI (r = .433; p < .0001), and BDI-II (r = .306; p < .0001) in caregivers.Conclusion: Staging PD according to the MNCD classification is correlated with caregivers’ strain and burden. Fundación Española de Ayuda a la Investigación en Enfermedades Neurodegenerativas y/o de Origen Genético; Alpha Bioresearch; Spanish Ministry of Economy and Competitiveness, Grant/Award Number: PI16/01575 2025-10-24T10:26:40Z 2025-10-24T10:26:40Z 2025-10-24T10:26:40Z 2023-12-21T12:37:11Z 2023-12-21T12:37:11Z 2023-12 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/11351/10742 Brain and Behavior;13(12) https://doi.org/10.1002/brb3.3295 Attribution-ShareAlike 4.0 International http://creativecommons.org/licenses/by-sa/4.0/ info:eu-repo/semantics/openAccess Wiley Open Access Scientia