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oai:recercat.cat:11351/107332024-06-06T08:39:12Zcom_2072_378070com_2072_378040col_2072_378092

Health-Related Quality of Life with Pembrolizumab in Patients with Locally Advanced or Recurrent or Metastatic Cutaneous Squamous Cell Carcinoma: KEYNOTE-629 Bratland, Åse MORTIER, Laurent Roshdy, Osama González, Rene Schachter, Jacob MUÑOZ COUSELO, EVA Institut Català de la Salut [Bratland Å] Head and Neck Oncology, Oslo University Hospital, Oslo, Norway. [Munoz-Couselo E] Servei d’Oncologia Mèdica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Melanoma and Other Cutaneous Tumours Unit, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Mortier L] Department of Dermatology, INSERM U 1189, Université Lille, Centre Hospitalier Regional Universitaire de Lille, Lille, France. [Roshdy O] Division of Dermatology, McGill University, Canada. [González R] Surgical Oncology, Centro Estatal de Cancerologiade Chihuahua, Chihuahua, Mexico. [Schachter J] Division of Oncology, Cancer Center (Oncology Institute), Sheba Medical Center–Tel Hashomer, Ramat Gan, Israel Vall d'Hebron Barcelona Hospital Campus Anticossos monoclonals - Ús terapèutic Pell - Càncer - Tractament Qualitat de vida HEALTH CARE::Environment and Public Health::Public Health::Epidemiologic Measurements::Demography::Health Status::Quality of Life DISEASES::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Glandular and Epithelial::Carcinoma::Carcinoma, Squamous Cell DISEASES::Neoplasms::Neoplasms by Site::Skin Neoplasms CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Antibodies, Monoclonal ATENCIÓN DE SALUD::ambiente y salud pública::salud pública::medidas epidemiológicas::demografía::estado de salud::calidad de vida ENFERMEDADES::neoplasias::neoplasias por tipo histológico::neoplasias glandulares y epiteliales::carcinoma::carcinoma de células escamosas ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias cutáneas COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas sanguíneas::inmunoproteínas::inmunoglobulinas::anticuerpos::anticuerpos monoclonales Advanced squamous cell carcinoma; Immunotherapy; Pembrolizumab Carcinoma de cèl·lules escamoses avançat; Immunoteràpia; Pembrolizumab Carcinoma de células escamosas avanzado; Inmunoterapia; Pembrolizumab Introduction At first interim analysis of KEYNOTE-629, health-related quality of life (HRQoL) with pembrolizumab was stable or improved over 48 weeks in recurrent or metastatic (R/M) cutaneous squamous cell carcinoma (cSCC). HRQoL results from the second interim analysis in R/M or locally advanced (LA) cSCC are presented. Methods Patients received pembrolizumab 200 mg every 3 weeks for ≤ 2 years. Change in EORTC Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) and EQ-5D-5L scores were exploratory end points. Primary analysis was performed at week 12 to ensure adequate completion/compliance. Descriptive analyses were also conducted through weeks 48 and 75 for the LA and R/M cohorts, respectively. Results At data cutoff (29 July 2020), mean scores in the LA cohort (n = 47) were stable from baseline to week 12 for EORTC QLQ-C30 global health status (GHS)/quality of life (QoL) (−0.27 points [95% confidence interval (CI) −10.93 to 10.39]), physical functioning (−1.29 points [95% CI  −8.77 to 6.19]), and EQ-5D-5L visual analog scale (2.06 [95% CI −7.70 to 11.82]). HRQoL remained stable through week 48 in the LA cohort; 76.6% and 74.5% of patients had improved or stable GHS/QoL and physical functioning scores, respectively. HRQoL continued to show stability or improvement through week 75 in the R/M cohort (n = 99); 71.7% and 64.6% of patients had improved or stable GHS/QoL and physical functioning scores, respectively. Conclusions Pembrolizumab has demonstrated antitumor activity and manageable safety. The current analysis shows pembrolizumab treatment preserved HRQoL. Collectively, these results support pembrolizumab as standard of care for LA or R/M cSCC. Trial Registration ClinicalTrials.gov, NCT03284424—September 15, 2017. Funding for this research and the journal’s Rapid Service Fee was provided by Merck Sharp & Dohme LLC., a subsidiary of Merck & Co., Inc., Rahway, NJ, USA. 2023-12-20T11:32:39Z 2023-12-20T11:32:39Z 2023-12 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Bratland Å, Munoz-Couselo E, Mortier L, Roshdy O, González R, Schachter J, et al. Health-Related Quality of Life with Pembrolizumab in Patients with Locally Advanced or Recurrent or Metastatic Cutaneous Squamous Cell Carcinoma: KEYNOTE-629. Dermatol Ther (Heidelb). 2023 Dec;13:3165–80. 2193-8210 https://hdl.handle.net/11351/10733 10.1007/s13555-023-01059-y 37943491 001100005100001 http://hdl.handle.net/11351/10733 eng Dermatology and Therapy;13 https://doi.org/10.1007/s13555-023-01059-y Attribution-NonCommercial 4.0 International http://creativecommons.org/licenses/by-nc/4.0/ info:eu-repo/semantics/openAccess application/pdf application/pdf Springer Scientia