2026-04-13T08:31:51Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/105062025-10-24T10:17:09Zcom_2072_378070com_2072_378040col_2072_378092

2025-10-24T10:17:09Z urn:hdl:11351/10506 Time-Tested Strategies in Modern Context: A Bibliometric Study of Chemotherapy’s Continued Importance in Colorectal Cancer Treatment Clar-Marmaneu, Helena García-Fernández, Alba Estela García-Fernández, Francisco Javier Còlon - Càncer - Quimioteràpia Recte - Càncer - Quimioteràpia Bibliometria DISEASES::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms Other subheadings::Other subheadings::Other subheadings::/drug therapy INFORMATION SCIENCE::Information Science::Communications Media::Publications::Bibliography as Topic::Bibliometrics ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias del sistema digestivo::neoplasias gastrointestinales::neoplasias intestinales::neoplasias colorrectales Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia CIENCIA DE LA INFORMACIÓN::Ciencias de la información::medios de comunicación::publicaciones::bibliografía como asunto::bibliometría Capecitabine; Chemotherapy; Colorectal cancer Capecitabina; Quimioteràpia; Càncer colorectal Capecitabina; Quimioterapia; Cáncer colorrectal In the landscape of colorectal cancer treatment, classical chemotherapeutic agents such as 5-fluorouracil, capecitabine, irinotecan, oxaliplatin, trifluridine, and tipiracil have historically played a pivotal role. This study presents a comprehensive bibliometric analysis of the top 100 most influential articles focusing on these classic chemotherapy drugs in the management of colorectal cancer. With this, we shed light on their current importance, despite the emergence of new therapeutic targets and treatments in the field of oncology. Systematically evaluating research outputs, this analysis reveals a prevalence of co-authorship among institutions, countries (led by the United States, China, and Europe), and researchers highlighting the global and collaborative nature of efforts in research, utilization, and development of these drugs. Three thematic axes lead the research: pharmacogenetics, the development of new pharmaceutical forms, and the use of adjuvants. This research serves as a foundation for future endeavors, aiding researchers, clinicians, and policymakers in making informed decisions about the direction of research and development in the dynamic field of colorectal cancer therapy. 2025-10-24T10:17:09Z 2025-10-24T10:17:09Z 2023-10-25T06:45:21Z 2023-10-25T06:45:21Z 2023-09-12 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/11351/10506 Cancers;15(18) https://doi.org/10.3390/cancers15184520 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess MDPI Scientia