2026-04-17T01:55:52Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/102722026-03-01T00:52:35Zcom_2072_378070com_2072_378040col_2072_378092

urn:hdl:11351/10272 Development of cancer surveillance guidelines in ataxia telangiectasia: A Delphi-based consensus survey of international experts Neves, Renata De Dios Perez, Blanca Panek, Rafal Jagani, Sumit Wilne, Sophie BHATT, JAYESH MAHENDRA Soler-Palacin, Pere Càncer - Propensió Decisió de grup Atàxia DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebellar Diseases::Cerebellar Ataxia::Spinocerebellar Ataxias::Ataxia Telangiectasia DISEASES::Neoplasms INFORMATION SCIENCE::Information Science::Systems Analysis::Delphi Technique ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::enfermedades cerebelosas::ataxia cerebelosa::ataxias espinocerebelosas::ataxia telangiectasia ENFERMEDADES::neoplasias CIENCIA DE LA INFORMACIÓN::Ciencias de la información::análisis de sistemas::técnica Delfos Ataxia telangiectasia; Cancer predisposition; International survey Atàxia telangiectàsia; Predisposició al càncer; Enquesta internacional Ataxia telangiectasia; Predisposición al cáncer; Encuesta internacional Background/Objectives Ataxia telangiectasia (A-T) is a multiorgan disorder with increased vulnerability to cancer. Despite this increased cancer risk, there are no widely accepted guidelines for cancer surveillance in people affected by A-T. We aimed to understand the current international practice regarding cancer surveillance in A-T and agreed-upon approaches to develop cancer surveillance in A-T. Design/Methods We used a consensus development method, the e-Delphi technique, comprising three rounds. Round 1 consisted of a Delphi questionnaire and a survey that collected the details of respondents' professional background, experience, and current practice of cancer surveillance in A-T. Rounds 2 and 3 were designed based on previous rounds and modified according to the comments made by the panellists. The pre-specified consensus threshold was ≥75% agreement. Results Thirty-five expert panellists from 13 countries completed the study. The survey indicated that the current practice of cancer surveillance varies widely between experts and centres'. Consensus was reached that evidence-based guidelines are needed for cancer surveillance in people with A-T, with separate recommendations for adults and children. Statements relating to the tests that should be included, the age for starting and stopping cancer surveillance and the optimal surveillance interval were also agreed upon, although in some areas, the consensus was that further research is needed. Conclusion The international expert consensus statement confirms the need for evidence-based cancer surveillance guidelines in A-T, highlights key features that the guidelines should include, and identifies areas of uncertainty in the expert community. This elucidates current knowledge gaps and will inform the design of future clinical trials. This study is funded by a grant from Action for A-T (ref. 20NOT05). Renata Neves is supported by a Doctoral Fellowship awarded by the College of Radiographers (ref. DF021). This study is supported by the National Institute for Health Research (NIHR) Applied Research Collaboration East Midlands (ARC EM). The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care. 2023-09-13T11:42:21Z 2023-09-13T11:42:21Z 2023-07 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Cancer Medicine;12(13) https://doi.org/10.1002/cam4.6075 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Wiley Scientia